Summer Co-op/ET Biophysics
About The Position
Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology). Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together. Department Description The Encoded Technologies (ET) group located in Cambridge, MA uses DNA-encoded libraries (DELs) to identify new chemical matter to impact a range of disease areas. Within ET, the Affinity Selections & Biophysics team focuses on applying the DEL technology to proteins of interest, screening for binders, and using biophysical assays to validate small molecule binders. For an overview of DNA-encoded library (DEL) technology, see: Clark, M. A. et al. Design, Synthesis and Selection of DNA-Encoded Small-Molecule Libraries. Nat. Chem. Biol. 2009, 5, 647-654. Chow, Y. T., et al. Selectivity Profiling of Bromodomain PROTACs Using Chemical Inducers of Proximity DNA-Encoded Library Screening. ACS Chem. Biol. 2025, 20, 2266-2276 Watch this before you apply! GSK Early Careers Top Tips: Learn practical advice from GSK on how to prepare a standout application and succeed in your early careers journey: GSK Early Careers Top Tips Job Description We are looking for a highly motivated student or recent graduate for a full-time, six-month co-op position within the Encoded Technologies Selections & Biophysics group. The focus of this placement will be biophysical techniques (examples in preferred qualifications) to assess protein folding and function, and expend the capabilities of the ET Biophysics platform by characterizing the functional impact of protein-ligand binding. As a member of our multi-disciplinary team, you will also gain insight into broader aspects of the DNA-encoded library technology and the early drug discovery process.
Requirements
- Must be pursuing a BS (prior full-time research experience required – co-op, internship, REU, etc.), MS, or PhD in chemical biology, biochemistry, biophysics, chemistry, or related disciplines.
- Must have knowledge and practical understanding of the scientific method and demonstrated experience in experimental design.
- Must be able to work full-time (35-40 hours/week) throughout the duration of the 6 month co-op (June ~ December 2026).
- Must have an active student status and/or within 12 months post-graduation from a BS or MS degree program. Post-doctoral candidates are not eligible.
- Must successfully pass a drug screen and background check prior to assignment target start date.
Nice To Haves
- Hands-on experience with biophysical and/or biochemical techniques (ex. trFRET, alphaLISA, SPR, DSF, MST, gel electrophoresis) and molecular biology techniques (ex. PCR).
- Experience with chemical inducers of proximity (i.e. PROTACs, molecular glues, or similar).
- Experience working with mammalian cells and/or cell lysates.
- Ambitious and organized individual who can tackle biophysical challenges.
- The ability to independently design experiments and apply trouble-shooting skills to optimize assay conditions.
Benefits
- Candidates who are hired for an on-site role or hybrid role, and reside outside of 50-miles from their assigned work location, are eligible for relocation stipend.
- GSK Interns and Co-ops are offered a competitive hourly pay rate and benefits.
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What This Job Offers
Job Type
Full-time
Career Level
Intern
