Sr Scientist I, Discovery Analytical Chemistry

Arrowhead Pharmaceuticals•Madison, WI

7d•$125,000 - $145,000

About The Position

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates. Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. The Position Arrowhead Pharmaceuticals is seeking a highly motivated Senior Scientist I to join our Discovery Analytical Chemistry team. In this role, you will play a critical part in advancing our protein and protein conjugate therapeutics by developing and implementing advanced LC-MS analytical strategies that support discovery and early process development activities. This is an opportunity to contribute at a high scientific level - designing innovative analytical solutions, influencing drug discovery direction, and collaborating cross-functionally to solve complex research challenges. The successful candidate will bring deep technical expertise in protein characterization and quantitation, along with the ability to translate analytical findings into meaningful insights that drive program decisions. You will serve as both a scientific leader and hands-on contributor, independently developing and optimizing analytical methods while mentoring junior scientists and helping shape analytical strategy within the team.

Requirements

PhD in analytical chemistry or close related fields with 2+ years relevant industry experience
Strong hands-on experience of using LC-MS and HPLC for proteins/protein conjugates characterization and quantitation
Expertise in sample preparation, peptide mapping, MS/MS peptide sequencing, glycosylation analysis, disulfide bond mapping, and post-translational modifications analysis
In-depth understanding of protein chemistry and analytical chemistry
Familiar with routine maintenance of mass spectrometers
Strong troubleshooting and problem-solving skills
Excellent ability for data interpretation and integration
Excellent communication and presentation skills
Ability and willingness to learn cutting edge technologies
Ability to prioritize the workload and adapt to fast changes

Nice To Haves

Open mind and willing to learn new technology
Experience with a wide range of analytical techniques
hands on experience with CE or MALS is a plus but not necessary

Responsibilities

Develop project and technical strategy within area of expertise
Apply advanced scientific principles, theories and concepts to a broad range of research problems and develop innovative solutions for analytical problems related to drug discovery and development
Design and execute analytical studies to facilitate drug discovery and platform development in various disease areas
Independently design and initiate development of analytical methods and improvement of existing ones
Serve as a project coordinator for on-going and new analytical method development
Work independently and collaboratively with teams to solve scientific /technical challenges
Develop and validate analytical methods to quantify and characterize drugs and impurities
Conduct sample analysis, analyze data/results, interpret the outcome of experiments and integrate scientific findings to gain further understanding of drug properties or synthetic/purification route
Represent team to present research findings to cross-function teams
Identify, propose and lead areas for initiatives /improvement
Influence and support drug discovery/development directions with scientific findings
Train and mentor junior scientists in the team
Other duties as assigned