Principal Scientist, Discovery Chemistry

Bristol Myers Squibb

1d • Onsite

About The Position

Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us. We are seeking a highly motivated and experienced Medicinal Chemist to join our team in Cambridge, MA. This role will play a key part in advancing antibody‑drug conjugate (ADC) programs within our Oncology portfolio, contributing scientific leadership from discovery through development.

Requirements

• Bachelor’s Degree and 8+ years of academic / industry experience (10+ years preferred) OR Master’s degree and 6+ years of academic / industry experience (8+ years preferred) OR PhD in Chemistry and 4+ years of experience (6+ years preferred).

Nice To Haves

• Prior experience supporting and advancing antibody‑drug conjugate (ADC) programs.
• Demonstrated expertise in the design and execution of multistep syntheses of complex organic molecules using modern synthetic methodologies.
• Strong problem‑solving skills and a deep understanding of reaction mechanisms and synthetic strategies
• Excellent written and oral communication skills, with a proven ability to thrive in a highly collaborative team environment.
• Applicants are encouraged to include a research summary (≤ 3 pages) highlighting relevant scientific contributions.

Responsibilities

• Design and synthesize linkers and payloads to support ADC programs in Oncology.
• Contribute to program strategy, experimental design, and data interpretation in close collaboration with cross‑functional project teams.
• Apply advanced organic chemistry techniques and contemporary medicinal chemistry approaches to solve complex, project‑specific challenges.
• Communicate scientific findings clearly and effectively through team discussions, reports, and presentations.

Benefits

• Health Coverage: Medical, pharmacy, dental, and vision care.
• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
• Work-life benefits include: Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays Based on eligibility, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day. All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Number of Employees: 5,001-10,000 employees