Senior Research Associate I/II - In Vivo

Monte Rosa Therapeutics Inc.•Boston, MA

60d•Onsite

About The Position

Monte Rosa Therapeutics is searching for a Sr Research Associate - In Vivo to assist in executing pivotal proof-of-concept studies in pre-clinical models in mice of inflammation, immunology, and oncology, and assist in the cross-functional development of our research strategy. The role involves interacting with team members to design and execute in vivo/ex vivo pharmacology studies aimed at defining the activity and mechanism of action of compounds. This person will work primarily in our Animal Care Facility, ideally 10am-6pm, to oversee and perform afternoon/evening and weekend dosing of animals as part of study protocols. This role will have the opportunity to expand their skill set at the lab bench by performing a variety of ex vivo/in vitro experiments.

Requirements

BS/MS in Biology, Pharmacology, Animal Science, or related field with minimum 4 years relevant experience in an industry setting.
Ability to work flexible hours, including evenings and weekends as needed, is a must.
Prior experience necessary in handling compounds for formulation preparation, with a strong emphasis on safety and proficiency in performing necessary calculations.
Strong experience in animal handling is required, including compound administration by multiple routes, harvesting tissue and blood samples, and performing necropsy techniques.
Strong organizational skills and attention to detail.
Willingness to learn new benchwork skills, including sample processing and cell culture.

Nice To Haves

AALAS certification at the ALAT level is preferred. LVT qualification is a plus.
Experience in culturing mammalian cell lines is advantageous.
Experience with pharmacodynamics assays of mouse tissue, including Western Blotting or JESS, ELISA/Mesoscale and flow cytometry is a plus, but not required.
Experience with surgical techniques is a plus.

Responsibilities

Perform basic and intermediate veterinary technical tasks in mice independently, including the following:
Administration of selected agents by PO, IP, SC routes.
Blood sampling techniques via multiple routes, including submandibular bleed.
Carry out tissue harvests at later time points based on study requirements.
Preparation of compound formulation for in vivo dosing.
Optimize and perform studies to define target biology in mouse models of inflammation, oncology and immunity for in vivo, in vitro and ex vivo applications.
Maintain accurate laboratory records/notebooks, procedures, and data summaries.
Perform evening and weekend dosing of animals as part of study protocols.
Conduct health checks to ensure animal welfare and identify any concerns.
Carry out tissue harvests at later time points based on study requirements.
Prepare and perform formulations for dosing studies.
Oversee breeding programs, including monitoring litters and documenting outcomes.
Assist with cage changes and husbandry tasks as needed.
Processing time-sensitive biological samples.