​Sr. Principal Infrastructure Architect – Manufacturing & Quality Systems

Eli Lilly and Company • Indianapolis, IN

40d

About The Position

At Lilly, we unite caring with discovery to make life better for people around the world. As we continue enabling advanced manufacturing capabilities, we are seeking a Sr. Principal Infrastructure Architect to provide strategic technology leadership across Indianapolis Parenteral Manufacturing (IPM), Indianapolis Device Assembly & Packaging (IDAP), and Indianapolis Device Manufacturing (IDM). The Sr. Principal Infrastructure Architect will design and govern IT infrastructure supporting GMP-regulated manufacturing execution, laboratory, and quality systems. You will ensure resilient, secure, and compliant platforms that enable operational reliability and digital transformation.

Requirements

• Bachelor's degree in Computer Science, Engineering, Information Systems, or related field.
• 5+ years of experience architecting IT infrastructure in GMP-regulated pharmaceutical or advanced manufacturing environments.
• 2+ years of working with MES, EWM/WMS, DCS, Industrial IoT networks, and S95 Level 2+ architectures.

Nice To Haves

• Demonstrated ability to lead multi-site infrastructure programs and influence executive technology decisions.
• Expertise in secure architecture design, disaster recovery, and operational resiliency.
• Experience supporting parenteral and/or device manufacturing.
• Familiarity with PharmaSuite, PMX, SAP EWM, or other MES/WMS platforms.
• Certifications or networking/security credentials preferred.
• Experience with hybrid cloud models, edge technology, and modern cybersecurity controls.
• Strong interpersonal skills and ability to build capability within teams through coaching and thought leadership.

Responsibilities

• Develop and maintain infrastructure architecture roadmaps for IPM, IDAP, and IDM, aligned with Tech@Lilly strategy.
• Lead infrastructure readiness for the transition from PMX to PharmaSuite and other key MES modernization initiatives.
• Architect secure, validated networking, compute, storage, and virtualization platforms supporting MES, EWM/WMS, Quality Systems, and S95 Level 2+ solutions.
• Provide technical leadership and escalation support for complex operational and cybersecurity challenges.
• Ensure compliance with GMP, GxP, CSV, and data integrity standards.
• Lead major infrastructure deployments and modernization programs across all three manufacturing areas.
• Partner with operations, engineering, automation, cybersecurity, and global architecture teams to deliver scalable solutions.
• Excellent communication and executive influence skills.
• Strong analytical capabilities with a proven track record of solving complex operational technology challenges.
• Experience working in fast-paced, operationally critical environments with multiple stakeholders and competing priorities.

Benefits

• Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance).
• In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Number of Employees: 5,001-10,000 employees