Senior Software Product Manager

Guardant HealthPalo Alto, CA
1dHybrid

About The Position

Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer. For more information, visit guardanthealth.com and follow the company on LinkedIn, X (Twitter) and Facebook. The Senior Product Manager, AI will drive the delivery of our AI product roadmap across both internal operations and customer-facing experiences. This role is accountable for executing the roadmap for conversational, generative, agentic, and predictive AI solutions that improve efficiency, scale service capacity, and elevate provider and patient engagement. Working with a diverse cross-functional team, the Senior PM will ensure AI investments align with Guardant’s strategic priorities. The ideal candidate brings deep knowledge of AI technologies, proven experience turning business needs into scalable solutions, and the ability to influence across multiple functions.

Requirements

  • 7+ years of product management experience, with 2+ in AI/ML-driven products.
  • Strong knowledge of conversational, generative, agentic, and predictive AI applications.
  • Proven success delivering AI-enabled solutions in healthcare, diagnostics, or other regulated industries.
  • Deep understanding of healthcare workflows across providers, patients, and operations.
  • Exceptional analytical skills, with the ability to tie AI initiatives to measurable outcomes (efficiency, scale, CX impact).
  • Excellent communication and stakeholder management skills, including executive presentations.
  • Bachelor’s degree in computer science, engineering, business, or related field.

Responsibilities

  • Product Roadmap Partner with stakeholders and Engineering to define and execute the roadmap for Screening AI solutions.
  • Prioritize high-impact use cases that scale operations, improve provider/patient experiences, and align with Guardant’s strategic objectives.
  • Stay ahead of AI and healthcare technology trends to ensure competitive and compliant solutions.
  • Product Delivery Lead the full product lifecycle from ideation through launch, adoption, and iteration.
  • Translate business needs into clear product requirements and partner with Engineering to deliver solutions.
  • Collaborate with cross-functional teams to deploy customer-facing AI solutions that streamline communication, create engaging content, and personalize outreach.
  • Partner with Operations to automate workflows, integrate AI into the CRM and support tools, and enable faster, more accurate decision-making.
  • Partner with Compliance and Legal to ensure AI solutions meet regulatory, privacy, and ethical standards.
  • Measurement & Stakeholder Engagement Define and track success metrics that demonstrate efficiency gains, customer impact, and scalability.
  • Communicate program updates, trade-offs, and outcomes to executive stakeholders with clarity and influence.
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