Senior Scientist, Structural Biology

Odyssey Therapeutics • Boston, MA

4d • Onsite

About The Position

We are seeking a highly motivated and skilled Structural Biologist to join the Odyssey team at our site in Boston where you will be a key contributor to the structural enablement of pipeline discovery projects. You will produce quality proteins in-house and with external partners in support of biophysical and structural analyses as well as assay development. You will employ cutting-edge structural techniques such as cryo-EM and X-ray crystallography in a cost-effective, efficient manner. You will use your expertise to probe mechanisms of action and structural aspects of protein-protein and protein-ligand interactions, and to guide protein therapeutic design. You will work within both small-molecule and protein therapeutic project teams. In this primarily lab-based role, you will be a key contributor to the application of internal and external resources and capabilities necessary to drive structural biology, biophysics, and assay development efforts.

As a critical member of the Odyssey team, you will be a key voice in the evolution of Odyssey’s science and platforms, offering opportunity for growth and impact. Odyssey prides itself as an organization with an exceptionally talented team with a broad range of skills. Together with your colleagues, you will help shape the Odyssey culture, strategic direction, and outcomes.

Requirements

• Outstanding collaboration skills
• Doctoral degree with a focus on structural biology, with demonstrated ability to employ cryo-EM or X-ray crystallography to visualize proteins and their complexes. Expertise with both techniques is preferred.
• Skilled in recombinant protein design, prokaryotic and eukaryotic protein expression, and protein purification for structural biology needs
• Minimum 5 years post-PhD research experience
• Ability to scientifically challenge others in a constructive manner
• Record of innovative thinking to propose and champion new ideas and solve problems
• Record of accomplishment as demonstrated by a strong record of publications and presentations in the application of construct design, protein production, and structural biology techniques
• Strong written and oral communication skills necessary to clearly deliver scientific results in a timely manner
• Excellent time management skills with the proven ability to manage and prioritize across multiple projects
• Ability to navigate and succeed in a fast-paced, interactive, and collaborative work environment

Nice To Haves

• Experience with the analysis and optimization of antibody/antigen interactions desired
• Working knowledge of medicinal chemistry, molecular and cell biology, biophysics, biochemistry, and assay development desired
• Experience working with structural biology CROs, from construct design to expression to structure solution desirable
• A passion and sense of urgency for delivering structural insights that make a meaningful impact on discovery programs

Responsibilities

• Actively contribute to internal and external efforts to ensure efficient protein design, protein expression and purification, sample preparation for structural studies, data collection, structure determination, and communication of high-quality structural information to project teams
• Contribute and collaborate on the design and enablement of structural biology strategies across a portfolio of small-molecule and protein therapeutic programs
• Collaborate with computational and medicinal chemists on structure-guided designs and actively participate in driving optimization of biologics and small-molecule chemical matter
• Partner with colleagues in biochemistry and biophysics, molecular and cell biology, and other functional groups to drive towards new medicines
• Participate in the scientific, technical, and operational aspects of structural biology for drug discovery programs
• Remain scientifically current with new technologies to enhance and complement structural biology capabilities including AI approaches

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree
• Number of Employees: 11-50 employees