Senior Scientist – Research Computational Biology (ARIA)

Amgen • Thousand Oaks, CA

1d

About The Position

Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Senior Scientist – Research Computational Biology (ARIA) What you will do Let’s do this. The ARIA Computational Biology team is seeking a talented and creative computational biologist to further our mission of serving patients by advancing and replenishing the Amgen therapeutic pipeline. In this role you will apply your expertise in data science and disease biology to accelerate the identification, prioritization, and validation of transformative therapeutic targets in a dynamic cross-functional research environment. Focus areas include: Extracting biological insight from complex multi-modal omics and screening data to characterize disease endotypes and mechanisms, identify novel targets and biomarkers, and test therapeutic hypotheses. Developing and leveraging methods/platforms to discover, prioritize, and validate targets across diverse diseases and therapeutic modalities Innovative research in close partnership with Amgen therapeutic area scientists, spanning both internal pipeline programs and external partnerships. Partnering with our data science and information systems teams to incorporate tools and analyses developed within ARIA Computational Biology into integrated R&D platforms. What we expect of you We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a computational biologist with these qualifications.

Requirements

• Doctorate in computational biology, bioinformatics, data science, or a related discipline [and relevant post-doc where applicable]
• Master’s degree and 3 years of relevant research experience
• Bachelor’s degree and 5 years of relevant research experience

Nice To Haves

• Strong programming skills (Python, R, Linux/Unix), familiarity with cloud computing environments, HPC, and collaborative coding practices (e.g. Git).
• Track record of designing and implementing creative and holistic computational strategies to address challenging research questions.
• Demonstrated expertise in the analysis and interpretation of single cell omics data.
• Excellent presentation and communication skills to convey complex findings to diverse audiences.
• Self-starter with a collaborative mentality and a drive for continuous growth.
• Strong background in cardiometabolic disease and/or immunology, including application to the interpretation of single-cell data.
• Experience leveraging and fine-tuning transcriptional foundation models, LLMs, and biomedical knowledge graphs to further research goals.
• Familiarity with public data resources (e.g. DepMap, Human Cell Atlas, TCGA, GTEx, and Tahoe-100M) frequently used to augment analyses of internally generated data.
• Experience developing and deploying tools and pipelines to endpoints such as interactive portals (e.g. RShiny apps), workflow management systems (e.g Nextflow), and agentic frameworks.

Responsibilities

• Extracting biological insight from complex multi-modal omics and screening data to characterize disease endotypes and mechanisms, identify novel targets and biomarkers, and test therapeutic hypotheses.
• Developing and leveraging methods/platforms to discover, prioritize, and validate targets across diverse diseases and therapeutic modalities
• Innovative research in close partnership with Amgen therapeutic area scientists, spanning both internal pipeline programs and external partnerships.
• Partnering with our data science and information systems teams to incorporate tools and analyses developed within ARIA Computational Biology into integrated R&D platforms.

Benefits

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models, including remote and hybrid work arrangements, where possible

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees