Senior Scientist, Protein Design and Antibody Engineering

Regeneron Pharmaceuticals • Village of Tarrytown, NY

2d • Onsite

About The Position

We are seeking a highly motivated Senior Scientist with deep expertise in structural biology, biochemistry, molecular and cellular biology to join our Bispecific Antibodies group. You will be part of an innovative team driving the design and optimization of novel antibody therapeutics by integrating structural biology data, AI/ML models, and high-throughput experimental validation. As a Senior Scientist within the Bispecifics Group, a typical day might include: Design and engineer novel antibody therapeutics using structural biology insights and AI/ML tools. Generate, interpret, and apply structural data (e.g., cryo-EM) to support antibody engineering efforts. Evaluate engineered antibodies through protein expression, purification and in vitro characterization. Collaborate cross-functionally on mechanism of action studies to support novel antibody engineering efforts. Analyze complex datasets independently and present results at group, department, and senior leadership meetings. Maintain accurate electronic records; prepare documents for regulatory filings, patent applications, and scientific publications. Stay current with advances in AI-driven drug discovery, structural biology, and antibody engineering; proactively bring new ideas into the team. This role may be for you if you: Are passionate about innovation and early-stage drug development. Are a team player and thrive in a fast-paced, collaborative environment. Possess excellent communication, organization, and time management skills. Can quickly adapt to changes and enjoy new challenges. Can comfortably manage multiple projects simultaneously. To be considered for this opportunity, you must have a Ph.D. in Biochemistry, Molecular and Cellular Biology, Structural Biology, or a related field with 0-5 years of relevant postdoctoral or industry experience and a strong track record of peer-reviewed publications. You must have strong proficiency in structural biology and protein biochemistry. Knowledge of immunology and antibody engineering is highly desired. Experience with high-resolution microscopy is a plus. Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive culture that provides comprehensive benefits, which vary by location. In the U.S., benefits may include health and wellness programs (including medical, dental, vision, life, and disability insurance), fitness centers, 401(k) company match, family support benefits, equity awards, annual bonuses, paid time off, and paid leaves (e.g., military and parental leave) for eligible employees at all levels! For additional information about Regeneron benefits in the US, please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other countries’ specific benefits, please speak to your recruiter. Please be advised that at Regeneron, we believe we are most successful and work best when we are together. For that reason, many of Regeneron’s roles are required to be performed on-site. Please speak with your recruiter and hiring manager for more information about Regeneron’s on-site policy and expectations for your role and your location. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business. For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location. Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc. Salary Range (annually) $109,900.00 - $179,300.00 Regeneron is a leading biotechnology company that invents life-transforming medicines for people with serious diseases. Founded and led for over 30 years by physician-scientists, our unique ability to repeatedly and consistently translate science into medicine has led to nine FDA-approved treatments and numerous product candidates in development, almost all of which were homegrown in our laboratories. Our medicines and pipeline are designed to help patients with eye diseases, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, neurology, infectious diseases and rare diseases. Regeneron is also proud of award winning culture of innovation, being recognized as a Great Place to Work in 2021, Fast Company’s Best Workplace for Innovators in 2020, and Forbes JUST companies in 2020, among others.

Requirements

• Ph.D. in Biochemistry, Molecular and Cellular Biology, Structural Biology, or a related field with 0-5 years of relevant postdoctoral or industry experience and a strong track record of peer-reviewed publications.
• Strong proficiency in structural biology and protein biochemistry.

Nice To Haves

• Knowledge of immunology and antibody engineering is highly desired.
• Experience with high-resolution microscopy is a plus.

Responsibilities

• Design and engineer novel antibody therapeutics using structural biology insights and AI/ML tools.
• Generate, interpret, and apply structural data (e.g., cryo-EM) to support antibody engineering efforts.
• Evaluate engineered antibodies through protein expression, purification and in vitro characterization.
• Collaborate cross-functionally on mechanism of action studies to support novel antibody engineering efforts.
• Analyze complex datasets independently and present results at group, department, and senior leadership meetings.
• Maintain accurate electronic records; prepare documents for regulatory filings, patent applications, and scientific publications.
• Stay current with advances in AI-driven drug discovery, structural biology, and antibody engineering; proactively bring new ideas into the team.

Benefits

• health and wellness programs (including medical, dental, vision, life, and disability insurance)
• fitness centers
• 401(k) company match
• family support benefits
• equity awards
• annual bonuses
• paid time off
• paid leaves (e.g., military and parental leave)

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree