Senior Scientist/Principal Scientist, Biologics Discovery

Synolo Therapeutics • Cambridge, MA

35d

About The Position

Synolo Therapeutics is seeking a collaborative and technically strong Senior Scientist or Principal Scientist to join our Biologics Discovery team. This role is a great fit for an antibody discovery and engineering expert who enjoys hands-on work at the bench, leads through influence and scientific excellence, and thrives in a fast-moving, early-stage biotech environment.

In this role, you will play a key part in advancing Synolo’s in-house biologics platform, including the discovery, engineering, and characterization of multispecific antibody therapeutics. You will have meaningful ownership of scientific direction and execution, working closely with cross-functional partners across discovery and development. As a member of a highly engaged team, you will help shape scientific strategy, support strong execution, and contribute to a collaborative, thoughtful, and results-driven culture.

Requirements

• Strong knowledge of canonical antibody sequence classes and structural concepts, including experience with alternative formats such as scFvs, VHHs, and multispecific formats.
• Hands-on expertise with yeast or phage display methods for antibody engineering, including library construction, panning/sorting, and sequence analysis.
• Proficiency with next-generation sequencing (NGS) and its application to antibody discovery and optimization workflows.
• Experience with handling significant numbers of sequences and related data, and proficiency in software to process antibody sequence-related data (Geneious Biologics, PipeBio, etc.)
• Excellent communication and interpersonal skills, with the ability to build productive working relationships across functions and with external contractors, consultants, and CROs.
• PhD, MS, or BS in Biochemistry, Molecular Biology, Biomedical Engineering, Chemical Engineering, or a related field, with a minimum of 12 years (BS), 8 years (MS), or 3 years (PhD) of relevant industry experience.

Nice To Haves

• Experience interfacing with protein design scientists and ML-related workflows
• Experience with automation and automated workflows for both data-handling and liquid-handling systems
• Experience interpreting data from biophysical characterization techniques such as BLI, SPR, DSF, and HPLC-based methods

Responsibilities

• Drive discovery and platform efforts: Lead research activities within the in-house biologics team, achieve project milestones, and advance platform development for biologic discovery and multispecific antibody engineering.
• Design and build libraries: Develop antibody libraries using in silico and rational approaches
• Antibody isolation and optimization: Experimentally isolate antibodies with desired properties through discovery workflows and analyze antibody sequences resulting from these workflows. Improve antibody leads through humanization, affinity maturation/optimization, and other engineering strategies to enhance performance and overall quality. Partner with Protein Science and Immunology teams to design, engineer, and refine multi-specific antibody constructs to maximize functionality
• Communicate and collaborate: Present results, recommendations, and next steps to project teams and cross-functional stakeholders to drive alignment, momentum, and program success.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree