Senior Scientist, Multi-Omics Analytics

Johnson & Johnson Innovative Medicine•Ambler, PA

About The Position

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit. Job Function: Data Analytics & Computational Sciences Job Sub Function: Data Science Job Category: Scientific/Technology All Job Posting Locations: Cambridge, Massachusetts, United States of America, La Jolla, California, United States of America, Spring House, Pennsylvania, United States of America, Titusville, New Jersey, United States of America Job Description: J&J Innovative Medicine develops treatments that improve the health of people worldwide. Research and development areas encompass oncology, immunology, neuroscience, cardiopulmonary and specialty ophthalmology. Our goal is to help people live longer, healthier lives. We have produced and marketed many first-in-class prescription medications and are poised to serve the broad needs of the healthcare market – from patients to practitioners and from clinics to hospitals. To learn more about Johnson & Johnson Innovative Medicine visit https://innovativemedicine.jnj.com/ Location: Spring House (PA), Cambridge (MA), Titusville (NJ), La Jolla (CA) Johnson & Johnson Innovative Medicine is seeking a Senior Scientist to join the Data Science & Digital Health (DSDH) organization, located at one of the sites in US. In this role, you will drive innovative computational biology, AI/ML model development, and integrative omics strategies to inform clinical development for precision medicine.

Requirements

Ph.D. in Bioinformatics, Computational Biology, Data Science, Biomedical Engineering, Computer Science, Artificial Intelligence or a related field.
2+ years postdoctoral or industry experience in large-scale omics data analysis (eg. proteomics, transcriptomics, genomics), preferably in clinical studies.
Strong background in AI/ML modeling for identifying pharmacodynamic signatures, treatment response signatures, disease signatures, and biological pathways, uncovering mechanistic insights linking to clinical outcomes.
Demonstrated technical expertise in high-performance and cloud computing, workflow design, and pipeline development and optimization.

Nice To Haves

Background in clinical omics, biomarker identification, and translational medicine.
Experience with network/pathway analysis, predictive modeling, mediation analysis and causal inference.
Familiarity with multi-omics models and integrating data across multiple platforms, datasets and batches.
Experience in defining research strategies and setting project milestones to drive innovation.
Excellent written and oral communication skills for multidisciplinary audiences.
Track record of impactful research with publications in top-tier journals.

Responsibilities

Lead the enhancement and application of the Clinical Omics framework — modular pipelines for identifying molecular signatures across clinical studies.
Provide technical leadership and define architecture strategies for the multiomics solution/product.
Design and execute advanced computational analyses, manipulate multiomics datasets (genomic, transcriptomic, proteomic), drive algorithm selection/application, develop AI/ML models and build reproducible pipelines.
Generate actionable insights, perform data visualization, and partner with cross‑disciplinary scientists to translate analytics into therapeutic impact.
Lead the design, development, and optimization of modular, scalable pipelines integrating genomics, transcriptomics, proteomics, and clinical metadata.
Drive multi-omics QC and integration across study designs and across assay platforms for clinical trial and real-world datasets.
Develop analysis workflow/pipelines/visualizations to identify/characterize biomarkers and pathways; generate mechanistic insights linking to clinical outcomes.
Collaborate cross-functionally to apply insights into portfolio programs to support precision strategy and clinical development (patient selection/subtyping, asset evaluation, regulatory discussion and marketing strategies).
Provide technical leadership and set project strategies, technical milestones, and delivery timelines.
Ensure computational workflows follow best practices for data integrity, reproducibility, and engineering.
Communicate the approach and findings effectively to diverse collaborators and stakeholders through internal/external reports, presentations and publications.
Enhance the organization’s Omics data foundation and technical capabilities.

Benefits

Subject to the terms of their respective plans, employees and/or eligible dependents are eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance.
Subject to the terms of their respective plans, employees are eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).
Vacation –120 hours per calendar year
Sick time - 40 hours per calendar year; for employees who reside in the State of Washington –56 hours per calendar year
Holiday pay, including Floating Holidays –13 days per calendar year
Work, Personal and Family Time - up to 40 hours per calendar year
Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child
Condolence Leave – 30 days for an immediate family member: 5 days for an extended family member
Caregiver Leave – 10 days
Volunteer Leave – 4 days
Military Spouse Time-Off – 80 hours