Senior Scientist, mRNA engineering
About The Position
NewLimit is a biotechnology company focused on extending human healthspan by developing medicines for age-related diseases through epigenetic reprogramming. They aim to restore regenerative potential in aged and diseased cells using functional genomics, pooled perturbation screening, and machine learning models. NewLimit is seeking a Senior Scientist to lead their mRNA production and engineering efforts. This is a hands-on, lab-based role that involves the synthesis, purification, and characterization of mRNA at large scales and high purities. The Senior Scientist will serve as the technical lead for the production workflow, connecting molecular design with the generation of high-quality material for in vivo and in vitro studies.
Requirements
- PhD in molecular biology, biochemistry, cell biology, or a related field or equivalent industry experience (5+ years).
- Deep hands-on experience with IVT and the specific challenges of scaling nucleic acid production.
- Proficiency with TFF and chromatography systems for the purification of large scale RNA batches.
- Ability to perform and interpret mRNA QC assays and troubleshoot mRNA production challenges.
- Strong experience in drafting technical reports and standardized protocols.
Nice To Haves
- Familiarity with Python or R for sequence analysis and secondary structure prediction.
- Understanding of how mRNA quality attributes impact Lipid Nanoparticle (LNP) formulation and delivery.
- Experience with complex plasmid design and bacterial scale-up for DNA template generation.
- Experience managing external contract manufacturing organizations (CMOs)
Responsibilities
- Execute and scale end-to-end mRNA production, including template preparation, in vitro transcription (IVT), and purification (TFF, chromatography).
- Implement rigorous quality control assays, including direct RNA sequencing, fragment analysis, dsRNA quantitation, and residual contaminant analysis.
- Author and maintain detailed SOPs and batch records, ensuring all production runs meet GLP standards.
- Independently design and execute experiments to improve mRNA sequence potency, specificity, and manufacturing performance.
- Train, manage, and mentor other team members on mRNA optimization and production workflows.
Benefits
- Health, dental, and vision insurance
- 401(k) with company match
- Paid parental leave
- Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays
- Meals and snacks on-site
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
