Senior Scientist - Immunology/Immunogenicity

Amgen • Thousand Oaks, CA

22h

About The Position

Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Senior Scientist – Immunology/Immunogenicity What you will do Let’s do this. Let’s change the world. The Department of Clinical Immunology within the Clinical Development at Amgen is seeking a highly motivated scientist to perform various in vitro assays to inform on the immunogenic risk of our protein therapeutic pipeline at the Amgen Thousand Oaks site. In this vital role, you will work closely with Clinical Immunology team members across sites, as well as other functional teams including Therapeutic Discovery, Research and Process Development.

Requirements

• Doctorate Degree Or Master’s degree and 2 years in Immunology or related experience Or Bachelor’s degree and 4 years in Immunology or related experience

Nice To Haves

• Expertise in RNA biology with a record of accomplishments including impactful first author peer-reviewed publications
• Extensive research experience, including postdoctoral training, in biophysics, biochemistry, molecular and cellular biology, or related disciplines
• Broad knowledge of assay development and NGS technologies
• Strong reasoning, data analysis, attention to detail, and problem-solving skills
• Excellent communication, interpersonal, and organizational skills
• Desire to be a team player in a dynamic, cross-functional environment

Responsibilities

• Perform various cell-based assays using primary human cells, such as dendritic cell or B cell co-culture with T cells using T cell proliferation, cell surface expression, and cytokine production as a readout.
• Development novel in vitro assays to assess immunogenic risk.
• Collaborate with colleagues to execute MHC-associated peptide proteomics (MAPPs) experiments to identify potential T cell epitopes within protein therapeutic candidates.
• Design and/or modify assays based on the mechanism of action of the drug candidate.
• Implement the cell-based assays using an automated, high throughput platform.
• Generate data, interpret, and summarize results for presentation at internal meetings as needed.
• Summarize results into study reports for incorporation into regulatory documents.
• Mentor a lab-based scientific team, driving project execution while supporting individual growth and long-term career development

Benefits

• Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans and bi-annual company-wide shutdowns
• Flexible work models, including remote work arrangements, where possible

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Number of Employees: 5,001-10,000 employees