Senior Scientist I-II, Conjugation

ADARx Pharmaceuticals Inc.•San Diego, CA

8d•Onsite

About The Position

We are seeking a highly motivated and qualified individual to join our Conjugation-Discovery Chemistry Department as a Senior Scientist I and work as part of a team to drive success. Ideal candidates will be self-motivated, independent, committed to the generation of high-quality data within a fast-paced and innovative research team. The Senior Scientist I will support ongoing RNA-based drug discovery projects in several therapeutic areas.

Requirements

Ph.D. in Chemistry, or related scientific discipline
3-5 years bioconjugation-related industrial experience.
Understanding of project timelines and deliverables and plans/coordinate project work accordingly with departmental, functional, and external stakeholders.
Strong problem-solving skills and a proactive attitude towards exploring new approaches.
Excellent written and verbal communication skills and effective presentation of complex scientific data to cross-functional and senior management teams are essential for this role.
In-depth knowledge of modern bioconjugation methods on antibodies (ADC, AOC), proteins, peptides, and other biomolecules.
Hands-on experience in the analytical characterization of the conjugates with strong analytical mindset. Proficiency in purification techniques such as RP-HPLC, FPLC, SEC, and IEX.
Proficiency working with Microsoft Office Suite Products.
Positive attitude and high personal and ethical standards. A strong team player with a passion for science and drug discovery.
Must be able to work independently as well in cross-functional team settings with supervision as needed.
Adaptable / Flexible - willing and able to adjust to multiple demands and shifting priorities as well as an ability to meet day-to-day challenges with confidence and professionalism.
Self-motivated with excellent interpersonal, organizational and communication skills with the ability to take a hands-on approach to work effectively in a dynamic and collaborative, fast-paced environment.

Nice To Haves

Team management experience
Previous experience with RNA/oligonucleotide therapeutics is preferred but not essential.
A track-record of impacting drug discovery programs through driving projects to key decision points.
In-depth knowledge of modern organic synthetic methods, purification and analytical techniques as well as medicinal chemistry.

Responsibilities

Design, synthesis, purification and analysis of oligonucleotide-conjugates on antibodies and other modalities. Develop and optimize conjugation protocols using novel chemistries and technologies for target drug delivery.
Evaluate SAR on the conjugates and drive the program by collaborating cross-functionally with the teams.
Track progress against project timelines, generate regular status updates, and communicate progress to the team.
Carry out assigned laboratory functions applying knowledge and skill in an accurate, timely manner.
Establish and maintain excellent working relationships with critical collaborative partners throughout the company to advance discovery research activities to pre-clinical development.
Contribute to the preparation of research reports and presentations for internal project teams, leadership team, and external audience.
Manage and maintain equipment, reagents and dedicated laboratory environment needed to carry out assignments.
Maintain updated and well-organized lab notebooks and batch records.
Execute daily laboratory operations with an approach designed to minimize risks and hazard waste streams.
Maintain all appropriate corporate standards for facility safety and hazardous material management.
Other duties as assigned.