Senior Scientist I/II, Bioconjugation

CytomX Therapeutics•South San Francisco, CA

9d•$150,000 - $190,000•Hybrid

About The Position

CytomX Therapeutics, Inc. is committed to changing the treatment of cancer with our novel PROBODY® therapeutic platform. Our commitment to transforming lives with safer, more effective therapies is driven by our curiosity and passion for innovation and our belief that by acting with integrity in an honest, respectful, ethical manner, we have the power to change lives. Our workplace embodies collaboration, open communication, celebrating our successes, and holding each other to the highest possible standards. CytomX’s robust and differentiated pipeline comprises therapeutic candidates across multiple treatment modalities including antibody-drug conjugates (“ADCs”), T-cell engagers, and immune modulators such as cytokines. CytomX’s clinical-stage pipeline includes CX-2051 and CX-801. Learn more at www.cytomX.com . You are passionate about life sciences and making a difference to cancer patients, their families, and healthcare providers. You will be responsible for Developing robust research scale conjugation process to support multiple PROBODY Drug Conjugate (PDC) discovery programs. Developing novel conjugation strategies/technologies to generate cutting-edge PDCs for the treatment of various cancers. Developing strategies for the chemical synthesis of novel linker payloads for PDCs Working closely with the CMC team to transition the PDCs into clinical development

Requirements

For Senior Scientist I: PhD in Chemistry, Biochemistry or Protein Chemistry or related discipline with 4+ years of experience in the biotechnology or biopharma industry with increasing responsibility
For Senior Scientist II: PhD in Chemistry, Biochemistry or Protein Chemistry or related discipline with 6+ years of experience in the biotechnology or biopharma industry with increasing responsibility
Hands-on experience in developing high-throughput conjugation methods is required.
Strong chemistry knowledge to help in optimization and validation of synthetic routes applicable for synthesis of payloads and linker-payloads is required.
Hands-on experience in bioconjugation methods (lysine, inter-chain cysteine and/or site-specific cysteine and others) is required.
Experience in synthesis, purification and characterization of ADCs on research scales (0.5 – 15 mg) and medium scales (500 mg-1 g) is required.
Experience in development of purification strategies to fractionate conjugated and unconjugated proteins and antibodies using various chromatographic and filtration techniques is required.
Expertise in analytical and biophysical characterization of ADCs including HIC, SEC, RP-HPLC, CE-SDS, ELISA, Biacore and DSC is required.
Must have outstanding communication (oral and written) and presentation skills.

Nice To Haves

Knowledgeable about the current status and the future of ADCs in treating diseases.
Experience in transitioning the ADCs from discovery to IND is preferred.
Experience in developing and executing procedures and protocols and preparing summary reports is preferred.

Responsibilities

Lead the bioconjugation group to support the discovery pipeline PDC programs.
Lead the CytomX bioconjugation lab move to Emeryville site in Q3, 2026
Develop robust research scale conjugation processes for various random and site-specific conjugation technologies.
Develop methods and strategies for next generation PDCs (dual-payload, bispecific, etc)
Develop analytical methods to fully characterize PDCs.
Develop gram scale conjugation process for PDCs to support Cyno tox studies.
Provide scientific input to CROs for synthetic chemistry involving payloads and linker payloads
Work collaboratively with members of Oncology Research and provide technical and scientific guidance.
Work collaboratively with CMC group to transition the conjugation process and analytics from discovery to development.
Support the Late-stage CMC activities for CX-2051 PDC program as needed
Manage the PDC workflow by prioritizing the needs from Oncology Research and CMC
Organize data and communicate results in internal and external scientific meetings