Senior Scientist I, Clinical Biomarker Development

Revolution Medicines • Redwood City, CA

8d • Hybrid

About The Position

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: The Senior Scientist I in Clinical Biomarker Development team, within Translational Medicine will play a key role in the design, execution, and interpretation of clinical biomarker strategies across Revolution Medicine’s oncology pipeline.

Requirements

• PhD in a relevant scientific discipline with 3+ years of relevant industry experience in clinical biomarkers, translational medicine, or related roles.
• Experience supporting oncology clinical trials with biomarker components.
• Familiarity with biomarker platforms such as genomic, transcriptomic and proteomic assays.
• Experience working with CROs and managing external vendors.
• Strong scientific communication skills and ability to work cross-functionally.

Nice To Haves

• Experience with targeted oncology therapies or RAS/MAPK pathway biology.
• Biological understanding of pancreatic, non-small cell lung and/or colorectal cancers is preferred.
• Familiarity with analytical software and analytical capabilities for integrating clinical and biomarker datasets.

Responsibilities

• Design and execute clinical biomarker strategies to support early response monitoring, patient stratification, and understanding resistance mechanisms.
• Support biomarker implementation for early- and late-stage oncology clinical trials.
• Oversee biomarker assay development, qualification, and sample analysis in collaboration with internal teams and external CROs.
• Analyze and interpret biomarker data in the context of clinical outcomes and present results to cross-functional teams.
• Contribute to clinical protocols, study reports, and regulatory documents (e.g., INDs, IBs, CSRs).
• Translate preclinical findings into clinically actionable biomarker hypotheses.
• Stay current with emerging biomarker technologies and trends in precision oncology.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree
• Number of Employees: 251-500 employees