Senior Scientist - Biology
About The Position
Location: Onsite. Cambridge, MA. #LI-Onsite About the role: The Oncology Translational Research (OTR) group in Biomedical Research is seeking a highly motivated individual to serve as a scientist investigating mechanisms of efficacy and resistance to cutting-edge cancer therapies in prostate cancer. Working collaboratively with groups across the drug development spectrum (target identification, drug discovery, data science, and early clinical development groups), you will design and execute translational studies. You will dissect mechanisms of therapeutic efficacy and uncover both intrinsic and acquired resistance pathways and translate these insights into next‑generation strategies that enhance efficacy, durability, and/or safety of clinically validated targets. As part of a larger team, your work will serve as the basis for patient stratification and development of new therapeutic strategies to improve patient response and overall outcome. The Oncology Translational Research (OTR) group in Biomedical Research is seeking a highly motivated individual to serve as a scientist investigating mechanisms of efficacy and resistance to cutting-edge cancer therapies in prostate cancer. You will dissect mechanisms of therapeutic efficacy and uncover both intrinsic and acquired resistance pathways and translate these insights into next‑generation strategies that enhance efficacy, durability, and/or safety of clinically validated targets. Working collaboratively with groups across the drug development spectrum (target identification, drug discovery, data science, and early clinical development groups), you will design and execute translational studies with the goal to develop new therapeutic strategies to improve patient response and overall outcome.
Requirements
- B.S./M.S. in biological/biomedical sciences
- Strong expertise in cell biology and multiple advanced molecular biology assays, preferably but not limited to studying clonal dynamics using barcoding technologies
- Robust experience studying resistance to small molecule therapies using molecular biology techniques
- Deep understanding of hormone driven cancer cell biology (e.g. prostate and breast cancer)
- Positive attitude, agility mindset, scientific curiosity, dedication, and excellent problem-solving skills
- Enthusiasm for scientific collaboration and working as part of a multi-disciplinary team.
Nice To Haves
- Proficiency with data mining and computational skills
- Experience completing single cell RNAseq and/or spatial transcriptomics
Responsibilities
- Lead mechanism‑of‑action studies using advanced cell biology and molecular biology approaches to interrogate therapeutic response and resistance.
- Design, develop, and execute in vitro assays to elucidate key aspects of prostate cancer biology, including resistance mechanisms to emerging therapies
- Design and engineer human cell line models to enable functional screening and deep mechanistic interrogation of resistance pathways.
- Collaborate with cross-functional teams, design, execute, analyze, document experiments, and communicate results in team settings.
- Stay current with scientific literature and advancements
Benefits
- US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits.
- In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Number of Employees
5,001-10,000 employees
