Senior Scientist, Biologics Design and Display, Discovery Biologics

Merck•Boston, MA

1d•Hybrid

About The Position

We are on a quest for cures and are committed to be the world’s premier, most research-intensive biopharmaceutical company. Our teams combine leading drug discovery capabilities and world-class R&D with the purpose of turning breakthrough science into life-changing medicines. We are seeking a Senior Scientist to join Biologics Design and Display team in the Boston Discovery Biologics group. The successful candidate will be an integral member of the team responsible for conducting in vitro display campaigns to generate novel therapeutic hits and optimized leads. They will directly contribute to the discovery of novel biologics as well as platform build and technology optimization efforts. They will stay current with scientific progress and drive continuous innovation of display technologies to consistently deliver high quality early biologics to support drug discovery across multiple therapeutic areas. As part of project teams, they will collaborate across groups to solve complex problems in disease biology and drug discovery. They will attend scientific conferences, contribute to publications, train and mentor junior stuff and interns, and help to set the group strategy. We recognize that the diversity in our team is our strength, and we are committed to creating an inclusive environment for all employees. Successful candidates must demonstrate inclusive behaviours in working with a diverse group of researchers to drive our core mission.

Requirements

PhD in Biology, Biochemistry, Analytical Chemistry, Bioengineering, Biophysics, Protein Sciences, Pharmaceutics, or a related life sciences discipline with 0-3 years of experience or MS with >5 years of industry experience
Expertise in using display-based screening methods
Expertise in molecular biology and high throughput laboratory methodologies
Strong presentation and publication record
Deep expertise in both phage and yeast display
Hands on experience in antibody or other molecular display technologies
Expertise in NGS technology, including NGS libraries generation, QC, sequencing and sequence analysis
Strong technical knowledge of molecular biology
Strong analytical and problem solving skills
Stay abreast of external advancements in the relevant scientific fields
Excellent communication and organizational skills

Nice To Haves

Hands on expertise in display library design and generation
Knowledge of computational and structure-guided approaches in display library design
Knowledge of antibody discovery technologies beyond display
Hands on expertise in using laboratory automation

Responsibilities

Perform yeast and phage display based biologics discovery screens to support therapeutic programs
Execute display-based lead optimization, including display library building, QC, and screening
Contribute to design and building of novel display libraries
Routinely use NGS, including NGS library generation, QC, sequencing and data analysis, for hit selection
Maintain accurate data and experimental records
Prepare presentations to effectively communicate experimental results in team meetings
Collaborate across different functional areas within Discovery Biologics and with key stakeholders in other departments
Stay abreast of external advancements in the relevant scientific fields
Promote the external reputation of our company’s Discovery Biologics

Benefits

The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.
We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.

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