Senior Scientist/Associate Director, Translational PKPD
About The Position
As a Senior Scientist/Associate Director in Translational PKPD, you will have the opportunity to drive strategy and provide global leadership in DMPK science on Antibody Drug Conjugates (ADCs), Radioconjugates (RCs) large molecules. Your role will involve providing projects with DMPK support, exploring the PK/PD/Efficacy relationships in pre-clinical models, using these models to build a quantitative understanding of the dose & schedule requirements for therapeutic intervention across different patient populations as a single agent and combined with other agents.
Requirements
- PhD in a discipline with a significant component of analysis and quantitation, such as pharmaceutical sciences, quantitative pharmacology, pharmacometrics, engineering, physics, or applied mathematics.
- Minimum 4 years of relevant industry experience in DMPK/preclinical/translational project-facing role within pharmaceutical R&D.
- Excellent interpersonal and communication skills coupled with strong influence and leadership skills.
- Specialist in tools such as WinNonLin/Phoenix NLME, R, SimCYP , NonMem, Berkeley Madonna and MATLAB.
- Track record of supporting PK, PKPD and TKPD aspects of projects, with a delivery focus and ability to meet timelines to prespecified quality and cost.
- Track record of demonstrating strong publication record demonstrating comprehensive understanding of DMPK and pharmacology/safety aspects of drug discovery and development
Responsibilities
- Representing the Translational PKPD group and providing overall scientific leadership for cross functional and external collaborations involving DMPK.
- Exploring the effects on target and pathway to understand the requirements for efficacy and set a candidate drug target profile (CDTP).
- Predicting human dose and regimen together with providing input into exposure and pharmacodynamic (PD) biomarker based decision criteria for early clinical trials.
- Driving learnings through back translation of early clinical exposure and PD data and providing prioritized future options for clinical testing.
- Leading and participating in Oncology strategic scientific initiatives and continuous improvement projects by providing expert DMPK knowledge and participating in the development of Discovery or Development strategies in PKPD.
- Working collaboratively and in continuity with other partner functions.
- Having a breadth of influence and impact across AstraZeneca Clinical Pharmacology and externally within their discipline.
Benefits
- qualified retirement programs
- paid time off (i.e., vacation, holiday, and leaves)
- health, dental, and vision coverage
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Education Level
Ph.D. or professional degree
Number of Employees
5,001-10,000 employees
