Senior Scientist, Antibody and Protein Engineering

Regeneron Pharmaceuticals•Village of Tarrytown, NY

7d•Onsite

About The Position

We are seeking a highly motivated and results-driven Senior Scientist to join our fast-paced and innovative Bispecifics & Antibody Engineering Department. You will be part of a group of diverse talents responsible for the design, production and characterization of next-generation antibody and protein therapeutics for infectious disease targets at Regeneron. This position will have a direct impact in innovative platform development at this exciting time, as significant advancements in antibody engineering has already propelled approvals of multiple next-gen antibody-based therapies in many indications. As a Senior Scientist, a typical day may include the following: Apply molecular and structural biology expertise to design innovative bi- and multi-specific antibodies with improved potency, selectivity and developability. Produce novel alternative format antibodies through mammalian expression and purification. Perform and troubleshoot in vitro bioanalytical and cell-based assays (SDS-PAGE, western blotting, flow cytometry binding, ELISA, qPCR). Collaborate with stakeholders in Infectious Disease to align on engineered antibody designs, research objectives, and next steps. Effectively communicate results to management and stakeholders in group and departmental meetings and maintain timely records in electronic lab notebooks. This role may be for you if: You are results-driven, can learn new skills quickly, and demonstrate a strong track record of troubleshooting assays. You have a background in infectious disease and antibody engineering. You are experienced in molecular biology and protein production. You have strong organizational, communication, and presentation skills. You enjoy working collaboratively in teams with diverse backgrounds and can handle multiple projects simultaneously.

Requirements

PhD in molecular biology, cell biology, biochemistry, or a related field
At least 1 year of relevant experience in academia or industry.
Hands-on experience with cloning, antibody expression in mammalian cell lines, antibody purification (i.e., experience with AKTA) and biochemical/biophysical characterization.
Results-driven
Ability to learn new skills quickly
Strong track record of troubleshooting assays
Background in infectious disease and antibody engineering
Experienced in molecular biology and protein production
Strong organizational, communication, and presentation skills
Ability to work collaboratively in teams with diverse backgrounds
Ability to handle multiple projects simultaneously

Nice To Haves

Familiarity with flow cytometry, neutralization assays, and/or structural biology

Responsibilities

Apply molecular and structural biology expertise to design innovative bi- and multi-specific antibodies with improved potency, selectivity and developability.
Produce novel alternative format antibodies through mammalian expression and purification.
Perform and troubleshoot in vitro bioanalytical and cell-based assays (SDS-PAGE, western blotting, flow cytometry binding, ELISA, qPCR).
Collaborate with stakeholders in Infectious Disease to align on engineered antibody designs, research objectives, and next steps.
Effectively communicate results to management and stakeholders in group and departmental meetings and maintain timely records in electronic lab notebooks.

Benefits

Health and wellness programs
Fitness centers
Stock for employees at all levels
Comprehensive benefits, which vary by location. In the U.S., benefits may include health and wellness programs (including medical, dental, vision, life, and disability insurance), fitness centers, 401(k) company match, family support benefits, equity awards, annual bonuses, paid time off, and paid leaves (e.g., military and parental leave) for eligible employees at all levels!

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