Senior Research Scientist, DNA-Encoded Library Screening
About The Position
C4 Therapeutics (C4T) (Nasdaq: CCCC) is a clinical-stage biopharmaceutical company dedicated to delivering on the promise of targeted protein degradation science to create a new generation of medicines that transforms patients’ lives. C4T is progressing targeted oncology programs through clinical studies and leveraging its TORPEDO® platform to efficiently design and optimize small-molecule medicines to address difficult-to-treat diseases. C4T’s degrader medicines are designed to harness the body’s natural protein recycling system to rapidly degrade disease-causing proteins, offering the potential to overcome drug resistance, drug undruggable targets and improve patient outcomes. For more information, please visit www.c4therapeutics.com . Job Summary C4 Therapeutics is seeking an enthusiastic, scientifically motivated Senior Scientist to join the DNA Encoded Library (DEL) Technology team within the Lead Discovery group. In this role, you will play a significant role in the implementation of our bespoke DEL platform utilized for identification of MonoDAC (molecular glue) degraders. Your background in DEL Selection design and data analysis, along with familiarity with targeted protein degradation will allow you to drive the technical and intellectual refinement and development of the MonoDAC DEL platform.
Requirements
- A Ph.D. or equivalent in Biology or a related field with a minimum of five years of relevant experience in the biotech/pharma setting; additional experience can compensate for required education
- Deep knowledge in DNA Encoded Library Technology with strong expertise in developing and applying DEL selections for ternary complex binders across target classes
- Thorough understanding of protein biochemistry and binding kinetics
- Familiarity with targeted protein degradation as a therapeutic modality
- Demonstrated success in providing high fidelity data to teams to drive downstream program decisions and operational vision to integrate DEL platform into broader Hit ID strategy
Nice To Haves
- Experience maintaining DEL specific instrumentation and inventory of all workflow reagents
- Solid experience in Next Generation Sequencing (NGS) library prep and sequencing run execution
Responsibilities
- Lead MonoDAC DEL laboratory efforts to advance drug discovery projects in a multidisciplinary, collaborative project team setting
- Provide DEL selection strategy in partnership with Director, DNA Encoded Library Platform and execute plans, interpret and communicate results, and recommend next steps to the project team
- Design and execute DEL selections for identification of molecular glues to be developed into degraders
- Contribute to intellectual development of next generation DEL technology for targeted protein degradation (TPD)/molecular glue identification
- Take ownership of platform performance and data integrity, partnering closely with bioinformatics/computational chemistry on data analysis
- Manage the operational and inventory needs of the DEL lab, including specific instrumentation and reagents
- Manage CRO interactions as needed
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Education Level
Ph.D. or professional degree
Number of Employees
101-250 employees
