Senior Research Scientist, Chemical Biology & Proteomics

AstraZeneca•Waltham, MA

About The Position

We are seeking a highly motivated and talented scientist to join our Chemical Biology & Proteomics (CBP) team at AstraZeneca in Waltham, MA. As a Senior Research Scientist, you will be an integral member of a team generating pre-clinical pharmacology data to understand efficacy and selectivity of therapeutic agents. You will have the opportunity to work with a team of cross-functional scientists and support the development of new and successful therapies for patients. If you’re inspired by the possibilities of science to make a difference and ready to discover what you can do – join us. Key Responsibilities Develop and employ chemical tools and proteomics technologies to provide impactful mechanistic insights for drug discovery projects across therapeutic areas Develop mass spectrometry-based methods to conduct covalent screens Design and execute experimental plans to understand target engagement and selectivity profiles of therapeutic agents, understand drug-induced proteome dynamics and investigate post-translational modifications (PTM) Represent CBP team, and communicate with project discipline leads, and contribute to generation of mechanistic hypothesis through interpretation of sophisticated proteomics data Maintain and troubleshoot LC-MS system Essential Requirements PhD with 2+ years of post-doctoral/industrial experience Knowledge and hands-on experience with sample preparation and method development on quantitative mass spectrometry (relative and/or absolute protein quantification) Experience with mass spectrometry-based covalent screening, and proven expertise with IP-MS or chemical probe-based enrichment MS workflows, and experience developing automated processes to analyze large number of samples for MS analysis Skilled in investigating compound effects under biochemical and cellular settings with quantitative mass spectrometry, e.g. PTMs, protein complexes perturbations, etc Experience in determining protein abundance and turnover by using quantitative proteomics technologies, such as TMT, SILAC, and/or label-free approaches and data independent acquisition (DIA) Expertise in data analysis and an ability to communicate data interpretation clearly Significant external reputation gained through professional recognition, external presentations and publications in high-impact journals Ability to contribute with a positive, result oriented and problem-solving attitude Desirable Requirements Experience in pre-clinical drug discovery Experience using Thermo Q-Exactive, Orbitrap Exploris, Eclipse, Astral Zoom or TimsTOF Experience with Xcalibur, Proteome Discoverer, MaxQuant, Skyline, Spectronaut and DB search engine tools Experience with liquid handling systems and robotic automation Familiarity with targeted proteomics is a plus Why AstraZeneca? At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There is no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development. Next Steps – Apply today! To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them. The annual base pay for this position ranges from $116,284.00 - $174,426.00 USD Annual. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Date Posted 09-Apr-2026 Closing Date 29-Apr-2026 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the world’s most serious diseases. But we are more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We’re curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We’re driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you’ll do work that has the potential to change your life and improve countless others. And, together with your team, you’ll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.

Requirements

PhD with 2+ years of post-doctoral/industrial experience
Knowledge and hands-on experience with sample preparation and method development on quantitative mass spectrometry (relative and/or absolute protein quantification)
Experience with mass spectrometry-based covalent screening, and proven expertise with IP-MS or chemical probe-based enrichment MS workflows, and experience developing automated processes to analyze large number of samples for MS analysis
Skilled in investigating compound effects under biochemical and cellular settings with quantitative mass spectrometry, e.g. PTMs, protein complexes perturbations, etc
Experience in determining protein abundance and turnover by using quantitative proteomics technologies, such as TMT, SILAC, and/or label-free approaches and data independent acquisition (DIA)
Expertise in data analysis and an ability to communicate data interpretation clearly
Significant external reputation gained through professional recognition, external presentations and publications in high-impact journals
Ability to contribute with a positive, result oriented and problem-solving attitude

Nice To Haves

Experience in pre-clinical drug discovery
Experience using Thermo Q-Exactive, Orbitrap Exploris, Eclipse, Astral Zoom or TimsTOF
Experience with Xcalibur, Proteome Discoverer, MaxQuant, Skyline, Spectronaut and DB search engine tools
Experience with liquid handling systems and robotic automation
Familiarity with targeted proteomics is a plus

Responsibilities

Develop and employ chemical tools and proteomics technologies to provide impactful mechanistic insights for drug discovery projects across therapeutic areas
Develop mass spectrometry-based methods to conduct covalent screens
Design and execute experimental plans to understand target engagement and selectivity profiles of therapeutic agents, understand drug-induced proteome dynamics and investigate post-translational modifications (PTM)
Represent CBP team, and communicate with project discipline leads, and contribute to generation of mechanistic hypothesis through interpretation of sophisticated proteomics data
Maintain and troubleshoot LC-MS system

Benefits

At AstraZeneca, we 're dedicated to being a Great Place to Work.
Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit.
There is no better place to make a difference to medicine, patients and society.
An inclusive culture that champions diversity and collaboration.
Always committed to lifelong learning, growth and development.
short-term incentive bonus opportunity
eligibility to participate in our equity-based long-term incentive program (salaried roles)
to receive a retirement contribution (hourly roles)
commission payment eligibility (sales roles)

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