Senior Research Associate/Specialist - in vivo and perfusions
About The Position
E11 Bio is on a mission to advance connectomics towards whole brain scale for humans and other mammals. We are a collaborative and interdisciplinary team of scientists and engineers engaged in a neuroscience moonshot project to develop a radical technology platform for scalable mammalian brain mapping. E11 Bio is a non-profit Convergent Research focused research organization located in Alameda, California, pursuing blue-skies neuroscience research yet operating like a nimble, tight-knit start-up. Read our technology roadmap. High quality tissue samples are the foundation of our science. We are seeking a hands-on in vivo senior technician to take full ownership of our animal perfusions and in vivo workflows. This role is responsible for executing and continuously improving perfusion, fixation, and injection protocols, including preparation of perfusates and active troubleshooting of tissue-quality issues. Working closely with experimental scientists, this person will help design, execute, and debug in vivo labeling experiments, and will play a central role in ensuring the reliability and reproducibility of tissue used for our mission to map the mouse brain.
Requirements
- Hands-on experience performing animal perfusions using PFA or related fixatives for neuroscience or brain tissue applications, with the ability to produce consistent, high-quality tissue.
- Demonstrated ability to quickly learn, independently own, and optimize complex biological workflows, including diagnosing and resolving tissue-quality or protocol failures.
- Experience with rodent handling, restraint, and basic health assessment in a research setting.
- Strong record of reliability, precision, and careful experimental documentation.
- Clear communication skills and a proven ability to collaborate effectively within interdisciplinary research teams.
Nice To Haves
- Mechanical or technical aptitude for maintaining, adjusting, or troubleshooting perfusion rigs, surgical setups, and related laboratory hardware.
- Experience with in vivo surgical techniques such as stereotaxic or retro-orbital viral injections (or strong interest and aptitude to train into these methods).
- Familiarity with downstream histology, imaging, or molecular tissue workflows.
- Interest in neuroscience and connectomics, with motivation to contribute to technically demanding, high-impact research.
Responsibilities
- Take ownership of all animal perfusions, including preparation of perfusates, execution of procedures, troubleshooting tissue-quality issues, and continuous improvement of fixation protocols.
- Execute and support in vivo surgical workflows, including stereotaxic and retro-orbital viral injections, post-operative monitoring, and animal welfare documentation.
- Apply scientific training to monitor, control, and systematically optimize key in vivo and perfusion parameters for tissue labeling + preservation.
- Collaborate closely with experimental scientists to design, execute, and troubleshoot in vivo labeling experiments, contributing technical judgment and experimental insight.
- Perform routine animal health checks and husbandry tasks as needed, with attention to health or behavioral changes that may impact experimental outcomes.
- Maintain accurate experimental records, reproducible protocols, and operational readiness of perfusion and surgical equipment.
- Contribute to a positive, collaborative lab culture and run small, focused experimental projects.
Benefits
- An opportunity to help change the world and work with some of the most talented and collaborative experts across scientific fields.
- An opportunity to gain experience on a field-defining moonshot effort.
- Excellent medical, dental, and vision insurance through a PPO plan; parental leave.
- 401K match to 6%
- Generous time off + paid holidays.
- Ample healthy and energizing food including daily lunches.
- Wellness allowance for fitness and wellness activities.
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Education Level
No Education Listed
Number of Employees
51-100 employees
