Senior Research Associate, Protein Analytics and Biophysics

Generate Biomedicines•Somerville, MA

2d•$85,000 - $111,000

About The Position

Generate Biomedicines is looking for a talented Senior Research Associate to join the Protein Analytics & Biophysics team within Therapeutic Assay Sciences. This role will contribute to the execution, optimization, and implementation of analytical and biophysical workflows that assess protein quality, binding interactions, stability, and developability in support of discovery programs and Generate Biomedicines’ machine learning-powered platform. The successful candidate will work hands-on with a variety of analytical and biophysical instrumentation and collaborate closely with scientists across cross-functional groups in a fast-paced, interdisciplinary environment . Here's how you will contribute: Execute fit-for-purpose analytical and biophysical assays to characterize protein quality attributes and binding interactions, including purity, aggregation, stability, heterogeneity, affinity, and kinetics Perform hands-on laboratory work using a range of analytical and biophysical techniques such as HPLC-based chromatography (e.g., SEC, IEX, HIC), capillary electrophoresis, DSF, DSC, DLS, and binding assays using technologies such as SPR or BLI Operate, maintain, and troubleshoot analytical and biophysical instrumentation and automated liquid handling platforms used in protein characterization workflows Design and execute experiments in support of established analytical and biophysical workflows, including optimization of assay conditions and throughput Accurately document experimental procedures, results, and observations in accordance with laboratory and data integrity standards Compile, review, and summarize data to support cross-functional project teams and downstream decision-making Assist with the evaluation and implementation of new analytical technologies and methodologies to expand or improve existing workflows Provide flexible experimental support across analytical and biophysical workflows to address evolving program and platform priorities Support rapid experimental iteration and troubleshooting to enable efficient progression of workflows Collaborate closely with scientists across Therapeutic Assay Sciences and partner functions to support discovery programs, platform initiatives, and evolving assay workflows through timely experimental data generation

Requirements

B.S./M.S. in a life science discipline with 5+ years (B.S.) or 3+ years (M.S.) of relevant research experience in an industry setting
Hands-on experience in protein analytical and biophysical characterization, including binding and developability assessments
Experience with high-throughput and/or automated analytical and biophysical platforms
Ability to adapt to evolving workflows and support multiple analytical and biophysical assay platforms
Exposure to data visualization or basic data handling tools used in analytical and biophysical workflows
Demonstrated ability to follow complex experimental protocols and execute laboratory workflows with attention to detail
Strong documentation and communication skills with experience maintaining accurate experimental records
Ability to work effectively in a collaborative, fast-paced, cross-functional research environment

Responsibilities

Execute fit-for-purpose analytical and biophysical assays to characterize protein quality attributes and binding interactions, including purity, aggregation, stability, heterogeneity, affinity, and kinetics
Perform hands-on laboratory work using a range of analytical and biophysical techniques such as HPLC-based chromatography (e.g., SEC, IEX, HIC), capillary electrophoresis, DSF, DSC, DLS, and binding assays using technologies such as SPR or BLI
Operate, maintain, and troubleshoot analytical and biophysical instrumentation and automated liquid handling platforms used in protein characterization workflows
Design and execute experiments in support of established analytical and biophysical workflows, including optimization of assay conditions and throughput
Accurately document experimental procedures, results, and observations in accordance with laboratory and data integrity standards
Compile, review, and summarize data to support cross-functional project teams and downstream decision-making
Assist with the evaluation and implementation of new analytical technologies and methodologies to expand or improve existing workflows
Provide flexible experimental support across analytical and biophysical workflows to address evolving program and platform priorities
Support rapid experimental iteration and troubleshooting to enable efficient progression of workflows
Collaborate closely with scientists across Therapeutic Assay Sciences and partner functions to support discovery programs, platform initiatives, and evolving assay workflows through timely experimental data generation