Senior Research Associate, Histology

Flagship Pioneering•Cambridge, MA

18d•$81,000 - $107,250

About The Position

We are searching for an experienced Sr. Research Associate to drive histology and related bio-analytics for platform development and therapeutic proof-of-principle. More broadly, we are looking for an individual who enjoys working with animal models and brings scientific rigor, intellectual curiosity, enthusiasm, and a desire to innovate new nucleic acid therapeutics. This individual will have the opportunity to work in a dynamic and fast-paced entrepreneurial environment, working both independently and as part of a highly collaborative and rapidly growing team.

Requirements

Masters or BS in relevant discipline with 5+ years of industry experience. Level will be based on experience.
Experience with in-vivo studies, ideally involving LNP delivery and/or nucleic-acid based therapeutics in rat, mouse, and NHP.
Experience with histological tissue analysis (IHC/IF, ISH, H&E, etc.) including tissue harvest, embedding, sectioning, staining, imaging and image analysis.
Deep hands-on experience with flow-cytometry, including panel design, execution and analysis.
Experience with tissue processing and ex-vivo analytical assays such as ELISA, FACS, MSD, qPCR, etc.
Strong communication and interpersonal skills.
Strong organizational, analytical, and problem-solving skills.
Ability to thrive in a fast-paced, multidisciplinary, and rapidly growing biotech environment

Nice To Haves

Experience with various mouse and rat models of diseases is a plus.
Experience performing in-vivo procedures in rodents, including preparation and administration of therapeutics and collecting material (blood, tissue, etc.) for ex-vivo analysis is a plus.

Responsibilities

Execution and analysis of bio-analytics, including histology, to assess efficacy, safety and biodistribution of novel nucleic acid therapeutics.
Provide scientific and technical perspectives to advance platform development.
Develop in-house capabilities to support work performed at CROs.
Effectively communicate experimental findings in oral, written, and visual formats.
Work independently and collaboratively in a multidisciplinary team environment.