Senior Research Associate

Ionis Pharmaceuticals•Carlsbad, CA

6d•$68,070 - $109,738

About The Position

Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We're pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We're building on our rich history, and we believe our greatest achievements are ahead of us. If you're passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career! Research Associate II / Senior Research Associate, Bioanalytical

Requirements

B.S./ M.S. in Analytical Chemistry, Biochemistry, Biology, or equivalent.
At least 3 - 5 years of biotech research, analytical or bioanalytical experience
Significant knowledge and hands-on experience with ligand binding and/ or RT-PCR assays; Mass spectrometry experience a plus
Experience with oligonucleotide, protein, peptide analysis is a plus.
Ability to solve complex scientific assay and project-based problems efficiently and constructively using independent thinking.
An ability to be productive and successful in an intense work environment
Strong analytical skill sets and outstanding verbal and written communication skills.

Nice To Haves

Mass spectrometry experience a plus
Experience with oligonucleotide, protein, peptide analysis is a plus.

Responsibilities

Support bioanalytical sample analysis activities for both early discovery and development programs by evaluating, developing/ optimizing bioanalytical methods for measurement of drug concentrations in a variety of biological matrices (ex. plasma, tissue).
Work with cross-functional teams supporting analysis of molecules consistent with the development project objectives.
Support oligonucleotide, bioconjugate and peptide/antibody quantification, gene editing sample analysis using ligand binding assays
Analyze samples independently and create data summary reports based on collected data to the study teams and project leads
Communicate and facilitate research assay transfer and troubleshooting at external laboratories and CROs as needed.
Day-to-day activities include in-lab sample analysis, assay optimization and/ or troubleshooting of complex assays for LBA (ELISA, ECL), and as needed Immunogenicity (ADA) assays.