Senior Research Associate, Cell & Molecular Biology

Flagship Pioneering•Cambridge, MA

1d•$81,000 - $107,000

About The Position

FL111 Inc., is a privately held, early-stage biotechnology company developing a groundbreaking small molecule technology platform. Our platform integrates experimental and computational approaches to unlock novel compounds to target high unmet-need diseases. FL111 is backed by Flagship Pioneering, bringing the vision and resources to guide FL111 from platform validation to real-world solutions that meaningfully improve patient care. FL111 is seeking a highly motivated Senior Research Associate with expertise in Cell and Molecular Biology to play a vital role in the company’s efforts to develop assays, screen compounds and integrate mechanism of action. This role requires a proactive, detail-oriented professional capable of working independently. Excellent written and verbal communication skills are essential. This is a unique opportunity to drive the growth of an early-stage biotechnology company in which you can contribute to the next frontier of small molecule medicines.

Requirements

Bachelor’s degree in Cell and Molecular Biology or a related field (e.g. Pharmacology, Biochemistry, Biomedical Engineering), with at least 2-4 years of laboratory experience in bio-pharmaceutical industry
experience with plate-based competition biochemical assays, Western analysis and immunofluorescence
experience with small molecule drug discovery, including compound management
hands-on experience with human/mouse cells (immortalized and primary) and using various delivery technologies (e.g. transfection, transduction, nucleofection, etc).
experience with ELN systems and data analysis workflows and database storage and retrieval
candidates of various experience levels will be considered. Position to be determined commensurate with experience.

Nice To Haves

Experience with CRISPR-based gene manipulation: knockout, interference activation
Experience with high content imaging, flow cytometry and quantitative PCR.
Hands-on experience with human PBMCs

Responsibilities

mammalian cell culture of both cancer cell lines and primary cells, including generation of genetically modified cell lines
confident, competent and agile in establishing new, and running existing, cell-based and biochemical assays
self-starter who can work cross-functionally between in vitro Biology and in vivo pharmacology groups
analyze complex datasets, use appropriate statistics, provide meaningful interpretation
collaborate with team to develop experimental plans, document results in an ELN, and make presentations to report findings to team