Senior Research Associate/Associate Scientist

5AM Ventures • Berkeley, CA

29d • $80,000 - $120,000

About The Position

We’re looking for teammates who relish the challenge and are compelled to leave a positive mark on the lives of the patients we serve alike. If embracing creativity and candor, thriving on challenges, and empowering your teammates to succeed excites and inspires you, join us as we champion hope and work to advance our aspiration to find therapies for renal disease.
The Role:
We’re seeking a dedicated and detail-oriented Senior Research Associate/Associate Scientist
with a strong background in biochemical assays to join our dynamic team and contribute to building our pipeline for kidney diseases. The successful candidate will play a crucial role in supporting our research efforts working alongside a team of scientists. The successful candidate will lead the execution of high-resolution protein and nucleic acid analyses,
bridging in vitro mammalian cell biology and in vivo tissue studies. We are looking for a versatile team member with a rigorous approach to data quality, a background in multi-modal assay development (including protein and RNA workflows), and a commitment to maintaining a safe, collaborative laboratory environment.

Requirements

• Bachelor's or Master’s degree in a relevant scientific field with at least 3-5 years of hands-on experience in protein biochemistry techniques. Prior biotechnology industry experience is required.
• Proven proficiency in both protein and nucleic acid techniques. Familiarity with automated protein analysis systems, such as the ProteinSimple Jess (Simple Western) is a plus.
• Demonstrated ability to troubleshoot and refine biochemical protocols with minimal supervision.
• Strong attention to detail with excellent organizational and time management skills.
• Effective communication and interpersonal skills, with the ability to work collaboratively in a team environment.
• Commitment to maintaining high-quality standards and adhering to laboratory safety protocols.

Responsibilities

• Execute routine and complex Western blots to assess target protein expression levels across diverse biological matrices.
• Develop and optimize protein purification, labeling and enrichment protocols to isolate protein targets and study molecular interactions
• Perform RNA-based assays (such as RNA extraction and RT-PCR) to validate target modulation and cellular responses.
• Adapt and execute assays in high-throughput formats to support validation of compound activity across programs.
• Analyze experimental results using software (such as ImageJ) and Graphpad Prism; maintain meticulous electronic laboratory notebooks (ELN).
• Adhere to strict laboratory safety guidelines, ensure a clean and organized work environment, and contribute to development of robust, reproducible SOPs
• Collaborate within the Discovery Biology team to optimize assay conditions, troubleshoot technical hurdles, interpret outcomes, and ensure consistent assay reproducibility
• Communicate findings to support aggressive project timelines and deliverables

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Number of Employees: 11-50 employees