Senior RA/Associate Scientist

Oxford BioTherapeutics • San Jose, CA

3d

About The Position

Oxford Biotherapeutics (OBT) is a clinical‑stage biotechnology company developing innovative antibody‑based therapeutics for the treatment of cancer. You will contribute directly to the pre‑clinical development of our immuno‑oncology pipeline.
Our proprietary OGAP® platform, the world’s largest cancer‑specific membrane protein library enables the discovery of novel, highly tumour‑specific antigens for first‑in‑class ADC, Bispecific T‑cell Engager (BITE®), and CAR‑based therapeutics. Our lead asset, OBT076, is in Phase 1b clinical development, supported by a strong internal and partnered pipeline with leaders such as Roche, Boehringer Ingelheim, and Zymeworks.
The Antibody Discovery Research Associate will support early-stage therapeutic and tool antibody programs by performing experiments that contribute to antibody generation using single B cell platforms, screening, and lead candidate selection.
The ideal candidate is highly organized, detail-oriented, and comfortable working in a fast-paced, collaborative research environment.

Requirements

• S. or M.S. in Molecular Biology, Immunology, Bioengineering, Biochemistry, or related field with 5+> years of experience working in a lab setting (industry experience preferred).
• Experience with antibody discovery platforms including single B cell, hybridoma, or display technologies.
• Proficiency in mammalian cell culture, in vitro assay development and flow cytometry.
• Strong organizational skills, attention to detail and ability to work independently and collaboratively.
• The ability to be a team player and collaborate with colleagues is critical.

Nice To Haves

• Strong understanding of B cell biology.
• Experience working with antibody sequences, including CDR identification and diversity analysis
• Hands-on experience with multi-color flow cytometry including panel design, staining, compensation, and data analysis/interpretation
• Hands on experience with BLI or SPR.
• Assay development and characterising antibodies using cell-based assays and flow cytometry.
• Comfortable working with high-throughput screening tools or automation.
• Experience with cell engineering technologies, such as transfection, electroporation, lentiviral transduction, and CRISPR.
• Experience with high-throughput antibody expression & purification.
• Experience with cytotoxicity assays using T cell engagers
• Innovative, detail-oriented, and quality-driven with a proactive mindset.
• Exceptional communication and interpersonal skills; able to translate complex data for diverse audiences.
• Highly motivated self-starter with scientific curiosity and a roll-up-your-sleeves attitude.
• Flexible and eager to learn new methods and optimize workflows.

Responsibilities

• Perform hands on antibody discovery work flows including cell culture, multi colour flow cytometry to sort and analyse rare immune cell populations.
• Develop, optimize and perform screening cell-based functional assays.
• Characterize antibodies by performing Elisa, SPR, BLI (Octet), Western blot.
• Maintenance of cell lines, freezing, thawing, expansion.
• Perform molecular biology tasks like PCR, cloning, transfection, sequence analysis, RNA/DNA purification methods, gel extraction as needed.
• Ensure all experimental work complies with established protocols and SOP’s.
• Maintain accurate and detailed experimental records and record all experimental data into Electronic Notebook.
• Contribute to troubleshooting, optimization, and continuous improvement of discovery workflows
• Compiling and analysing data by FlowJo, GraphPad Prism, and Excel.
• Conduct analysis and effectively communicate results and present data at internal meetings.
• Collaborate with cross functional teams to align with project goals.
• Committed to fostering an inclusive, collaborative, and innovative research environment.

Benefits

• Medical, dental, and vision insurance for employees and dependents
• Flexible Spending Account (FSA)
• Short‑Term Disability (STD), Long‑Term Disability (LTD), Basic Life & AD&D, and Supplemental Life insurance
• 401(k) plan
• 120 hours of Paid Time Off + 5 sick days per year
• 11 public holidays
• Annual bonus program
• Employee referral bonus program
• New hire stock options

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Number of Employees: 11-50 employees