Senior Principal Scientist | Antibody-siRNA Bioanalytical & Biodistribution Strategy Lead

Amgen • South San Francisco, CA

1d

About The Position

Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Senior Principal Scientist - Antibody-siRNA Bioanalytical & Biodistribution Strategy Lead What you will do Let’s do this. Let’s change the world. In this vital role you will add to our diverse team in Pharmacokinetics & Drug Metabolism – Bioanalytical Sciences (PKDM-BA) to advance our growing siRNA research portfolio. You will lead the strategy and execution of innovative bioanalytical platforms to measure antibody-siRNA conjugates in preclinical samples, both in vitro and in vivo, for characterizing ADME and elucidating pharmacokinetics and pharmacokinetic-pharmacodynamic relationships. In addition to leading teams within PKDM-BA, you will be a project team representative contributing to multidisciplinary teams composed of experts in chemistry, biology, toxicology, clinical pharmacology and the like to drive clinical candidate selection and successfully file regulatory applications.

Requirements

• Doctorate degree [and relevant post-doc where applicable] in pharmacology, biochemistry or a related-scientific discipline and 3 years of industry experience
• Master’s degree in pharmacology, biochemistry or a related-scientific discipline and 6 years of industry experience
• Bachelor’s degree in pharmacology, biochemistry or a related-scientific discipline and 8 years of industry experience

Nice To Haves

• Extensive knowledge of antibody-siRNA conjugate ADME and pharmacokinetics; Experience with respect to other siRNA modalities, antibody-drug conjugates, peptide conjugates, biologics and/or small molecules is also highly desirable
• Experience investigating biodistribution and metabolism of siRNA conjugated to a tissue-targeting ligand
• Expertise in antibody-siRNA bioanalytical approaches and considerations
• Extensive experience with ligand binding assays (specifically immunoassay and hybridization assays) and LC/MS bioanalytical platforms; Experience with respect to RT-qPCR and/or RT-ddPCR is also highly desirable
• Exceptional written and verbal communication skills
• Experience with regulatory filings for antibody-siRNA conjugates and/or other targeted delivery siRNA therapeutics

Responsibilities

• Lead strategy to establish innovative bioanalytical platforms to measure antibody-siRNA conjugates in preclinical samples (in vitro and in vivo)
• Lead strategy to establish innovative in vitro ADME assays for antibody-siRNA conjugates
• Design, execute, and interpret results from in vivo studies characterizing pharmacokinetics, pharmacokinetic-pharmacodynamic relationships, tissue distribution, and toxicokinetics of antibody-siRNA conjugates
• PKDM-BA project team representative for antibody-siRNA conjugates and other siRNA modalities
• Lead and execute on preparation of the pharmacokinetic written summary for regulatory applications
• Mentor and cross-train PKDM-BA scientific colleagues
• Build and foster cross-functional collaboration across Research and Development to advance siRNA therapeutics from discovery to clinical proof of concept

Benefits

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees