Senior / Principal Operations Manager, Drug Discovery (Medicinal Chemistry and DMPK)

Calico•South San Francisco, CA

16d•Onsite

About The Position

Calico seeks a Drug Discovery Senior / Principal Operations Manager as a key driver in advancing our preclinical drug discovery pipeline from hit generation through to the nomination of a clinical candidate. You will be responsible for bridging the gap between internal scientific strategy and internal/external execution. This role requires exceptional organizational skills, deep scientific understanding of the drug discovery process, the Design-Make-Test-Analyze (DMTA) cycle and an ability to effectively manage complex, multi-disciplinary projects executed primarily through external CROs. The successful candidate will be able to effectively communicate among the relevant internal and external stakeholders to achieve robust, efficient pipeline operations that support the goals of Calico Drug Discovery. The Operations Manager acts as the central hub for communication, planning, and execution, ensuring projects are delivered on-time, within scope, and on-budget, while maintaining the highest scientific and productivity standards for successful preclinical candidate nominations.

Requirements

Ph.D. in Chemistry or a related field with 2+ years of industrial experience or an M.S. with 6+ years of progressive responsibility in drug discovery
A proven ability to manage diverse scientific workflows through external partnerships is essential, including experience directing international and domestic CROs across multiple disciplines
Deep scientific literacy in drug discovery processes (e.g., DMTA cycle, target identification, hit-to-lead, lead optimization, preclinical safety assessment)
Experience with project management tools (Smartsheet, Gantt, Excel, PowerPoint, Word) and drug discovery informatics (ChemDraw, corporate compound databases, Chemoinformatics Analysis and Visualization tools, ELN systems)
Project management experience with demonstrated proficiency in tracking logistics of compound movement through target screening funnels across a portfolio of projects is desired
Ability to maintain alignment with internal and external stakeholders while managing project scope, deliverables, risks, and resources is expected
Outstanding organization and planning skills to effectively manage competing priorities, resources, and activities within and across a diverse portfolio of projects and programs is required
Exceptional negotiation, communication, and interpersonal skills required to manage complex relationships with external vendors and internal stakeholders
Ability to manage budgets and accurately forecast external expenditures
Ability to confidently make decisions that align with the scientific strategy in a fast-paced environment
Strong risk assessment and problem-solving skills, with an ability to function effectively in a fast-paced, high-pressure environment
Ability to effectively communicate complex information, issues, and potential solutions across the organization, including leadership and external collaborators
Ability to foster partnerships and effective collaboration within and across teams
Ability to design and implement medium-to-large-scale process improvements
Must be willing to work onsite at least four days a week

Nice To Haves

PMP (Project Management Professional) or equivalent certification is highly preferred
Demonstrated ability to apply structured PM methodologies (Agile, Waterfall, or Lean) to accelerate drug discovery timelines and optimize CRO deliverables

Responsibilities

Act as the "glue" between Chemistry, Biology and DMPK teams to ensure seamless data flow and resource allocation
Rigorously monitor CRO performance against the agreed-upon SOW, budget, and timeline, proactively identifying and mitigating potential delays or scope creep
Ensure clear and consistent communication, monitor data quality, protocol troubleshooting and technical alignment among all internal team members/labs, external CROs, and collaborators
Facilitate and document team meetings to enable cross-functional communication, decision-making, and alignment with internal and external stakeholders
Work closely with Drug Discovery Project Lead and internal scientific functional leads to define clear milestones, deliverables, and decision points (Go/No-Go criteria)
Meet regularly with stakeholders to assess the states of ongoing projects, identify current or projected problems, anticipate delays before they happen and proactively suggest/implement solutions
Lead and/or contribute to the development of processes and tools to enable planning, prioritization, tracking, and execution of pipeline projects
Ensure the seamless and compliant transfer of data, materials, and biological samples between internal facilities and external partners
Manage contracts and financial tracking related to external spend, processing invoices, and forecasting future expenditures with finance and procurement teams
Ensure that business critical contracts are executed in a timely manner
Develop and distribute regular project status reports detailing progress, key findings, risks, and mitigation strategies to senior management and internal stakeholders
Organize and manage project documentation, ensuring all project records and data summaries are centralized, current, and audit-ready
Develop and manage project plans and integrated timelines for pipeline projects as needed