Senior Medical Director, IRF5 Program

Kymera Therapeutics, Inc. • Watertown, MA

47d • $330,000 - $380,000

About The Position

The Senior Medical Director, IRF5 Program will serve as the clinical lead for one or more indications within Kymera's IRF5 clinical development program, a first-in-class therapeutic approach, leveraging targeted protein degradation to modulate innate immune signaling in immune-mediated diseases. This individual will be responsible for driving the clinical strategy of the program, including clinical trial design, execution, data interpretation, and regulatory interactions. This is a unique opportunity to help shape the clinical development of a first-in-class therapy with the potential to transform treatment paradigms in autoimmune disease. This role requires deep clinical insight, cross-functional collaboration, and leadership in advancing novel therapies from early clinical development through late-stage trials.

Requirements

• MD or MD/PhD with board certification in Rheumatology, Immunology, or a related discipline. Candidates with alternative certifications and substantial clinical development experience in relevant therapeutic areas will also be considered.
• Minimum of 4 years of experience in clinical drug development, ideally in biotechnology or pharmaceutical settings.
• Experience interacting with global regulatory agencies (e.g., FDA, EMA) and preparing briefing documents for regulatory submissions.
• Proven track record in designing and executing clinical trials (Phase I-III) and contributing to successful regulatory interactions.
• Strong understanding of translational science, biomarkers, and mechanistic drug development.
• Demonstrated ability to lead cross-functional teams and manage multiple programs in parallel.
• Entrepreneurial mindset and passion for advancing first-in-class therapies in a collaborative, science-driven environment.
• Excellent leadership, communication, and collaborative skills; ability to thrive in a fast-paced, matrixed environment.

Responsibilities

• Serve as the clinical lead for one or more clinical indications within the IRF5 program, overseeing all aspects of clinical strategy and execution.
• Integrate translational and biomarker data into clinical strategy to refine patient selection and endpoint development.
• Lead the design and implementation of clinical studies, ensuring scientific rigor and patient safety.
• Collaborate with external partners, academic institutions, and consortia to advance the scientific and clinical development strategy.
• Provide strategic medical leadership to cross-functional teams, including development sub-teams and clinical study teams.
• Provide medical oversight during clinical trial conduct, including safety monitoring, data review, and protocol amendments as needed.
• Contribute to the development of clinical and regulatory documents (protocols, IBs, CSRs, regulatory submissions).
• Contribute to hiring, coaching, and development of clinical development talent.
• Represent Kymera in scientific, regulatory, and clinical forums, including interactions with KOLs, investigators, and advisory boards.

Benefits

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $330,000 - $380,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate's depth of experience and the capabilities they bring to the position.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Industry: Professional, Scientific, and Technical Services
• Education Level: Ph.D. or professional degree
• Number of Employees: 101-250 employees