Senior Medical Director, Integrated Evidence Generation – Nephrology

Travere Therapeutics • San Diego, CA

6d • $233,000 - $315,000 • Remote

About The Position

Be a part of a global team that is inspired to make a difference in the lives of people living with rare disease. At Travere Therapeutics, we recognize that our exceptional employees are vital to our success. We are a dedicated team focused on meeting the unique needs of rare patients. Our work is rewarding – both professionally and personally – because we are making a difference. We are passionate about what we do. We are seeking talented individuals who will thrive in our collaborative, diverse, fast-paced environment and share in our mission – to identify, develop and deliver life-changing therapies to people living with rare disease. We stick by our values centered on patients, courage, community, and collaboration to pursue our vision of becoming a leading biopharmaceutical company dedicated to the delivery of innovation and hope to patients in the global rare disease community. At Travere Therapeutics, we are in rare for life. We continue to courageously forge new paths as we move toward a common goal of elevating science and service for rare patients.
Position Summary: The Sr. Medical Director, Integrated Evidence Generation – Nephrology will serve as the strategic architect of Travere’s Medical Affairs–led evidence infrastructure. This role is responsible for defining and executing a multi-year integrated evidence strategy spanning post-approval interventional and non-interventional studies, investigator-sponsored research (ISR), collaborative research, real-world evidence (RWE), and lifecycle management (LCM). The Sr. Medical Director will chair the Evidence Generation Committee and act as the senior medical authority on post-approval and lifecycle evidence, partnering cross-functionally to strengthen Travere’s scientific credibility and long-term asset value. In a growth-stage biotech environment, this role will also serve as a key member of the Nephrology Medical leadership and may contribute to broader TA priorities based on experience, expertise, and evolving organizational needs. The successful candidate must bring prior experience as a Medical Director, evidence generation leadership, deep knowledge of nephrology (preferred) and healthcare delivery, along with the ability to integrate these insights to shape Travere’s Medical Affairs efforts. The ideal candidate will own evidence generation, drive strategic initiatives, support cross-functional partners, and foster external expert relationships, ensuring the success of Travere’s nephrology portfolio.

Requirements

• Advanced scientific degree (MD, PharmD, PhD)
• 8+ years of experience in Medical Affairs, clinical research, evidence generation, or other relevant experience
• Deep expertise in interventional and non-interventional study design, RWE methodologies, ISR governance, post-approval and lifecycle evidence strategy
• Experience contributing to or leading lifecycle management planning
• Demonstrated ability to influence executive decision-making
• Proven ability to operate in a lean, high-accountability biotech environment

Nice To Haves

• Demonstrated ability to influence important customers, challenge common perceptions, and implement medical affairs tools to improve patient care and outcomes.
• Exemplary verbal and written communication skills, including formal presentation skills, and well-developed interpersonal skills.
• Strong organizational skills with the ability to prioritize and execute against key objectives and deliverables, on time and within budget.
• Demonstrates the highest ethical standards with strong knowledge of and adherence to applicable regulatory, legal, and compliance requirements.
• Highly adaptable and resourceful, with the ability to prioritize, manage complexity, and collaborate effectively in a fast-paced, cross-functional environment.
• Ability to travel up to 40% (ASN, ERA-EDTA, NKF, KOL symposiums, etc.) and manage a rigorous schedule which may require some evenings and weekend availability.
• All positions have an essential job function to perform face-to-face work with colleagues and/or onsite in San Diego.

Responsibilities

• Integrated Evidence & Lifecycle Strategy
• Serve as Medical Affairs evidence leads for LCM planning and execution
• Identify and address evidence gaps supporting label expansion, new subpopulations, combination strategies, durability, and long-term safety
• Ensure evidence strategy strengthens regulatory positioning and lifecycle business cases
• Partner with Clinical Development and Regulatory to align post-approval evidence with future development plans
• Evidence Governance & Investment Oversight
• Chair and govern the cross-functional Evidence Generation Committee
• Establish clear prioritization criteria and portfolio governance processes
• Oversee investment decisions across MA-led studies, ISR, collaborative research, and RWE
• Ensure evidence investments are strategically aligned to lifecycle objectives
• Provide executive-level updates to TA and GMA leadership
• ISR & Collaborative Research Strategy
• Establish and lead ISR governance framework within the TA
• Define scientific prioritization aligned to strategic data gaps
• Curate an ISR and collaborative research portfolio that advances guideline positioning, access strategy, and future development opportunities
• Oversee partnerships with academic institutions, research networks, and Centers of Excellence
• Monitor scientific impact and return on investment
• Real-World Evidence (RWE) Leadership
• Co-lead RWE strategy in partnership with Patient Access/HEOR
• Align RWE initiatives with lifecycle, guideline, and access priorities
• Identify and evaluate strategic data partnerships and registries
• Ensure RWE outputs inform clinical practice insights, compendia engagement, and value demonstration
• Build & Scale Medical Affairs–Led Research Capability
• Establish and expand Travere’s Medical Affairs–led research capability
• Develop scalable frameworks to support post-approval interventional, non-interventional, and implementation science studies
• Identify opportunities where MA-led research complements Clinical Development and strengthens lifecycle strategy
• Operationalize compliant, fit-for-purpose execution models appropriate for Travere
• External Scientific Leadership & Therapeutic Area Partnership
• Represent Travere in strategic society research initiatives and academic collaborations
• Engage key opinion leaders, steering committees, and research consortia
• Serve as internal authority on evolving evidence methodologies and standards
• Contribute to cross-functional planning, advisory boards, and broader Medical Affairs priorities based on expertise and organizational needs
• Collaborate with field medical teams to execute external expert interactions, evidence-generation activities, and training programs aligned with emerging evidence and medical strategies.

Benefits

• premium health
• financial
• work-life and well-being offerings for eligible employees and dependents
• wellness and employee support programs
• life insurance
• disability
• retirement plans with employer match and generous paid time off
• competitive compensation package includes a combination of both cash compensation (base pay and short-term incentive) and long-term incentive compensation (company stock), designed to recognize, retain, and reward employees.

What This Job Offers

• Job Type: Full-time
• Career Level: Director
• Education Level: Ph.D. or professional degree