Senior Manager, Cyber Security Operations

Ardelyx • Waltham, MA

18h • $167,000 - $205,000

About The Position

Ardelyx is a publicly traded commercial biopharmaceutical company founded with a mission to discover, develop and commercialize innovative first-in-class medicines that meet significant unmet medical needs. Ardelyx has two commercial products approved in the United States, IBSRELA® (tenapanor) and XPHOZAH® (tenapanor). Ardelyx has agreements for the development and commercialization of tenapanor outside of the U.S. Kyowa Kirin commercializes PHOZEVEL® (tenapanor) for hyperphosphatemia in Japan. A New Drug Application for tenapanor for hyperphosphatemia has been approved in China with Fosun Pharma. Knight Therapeutics commercializes IBSRELA in Canada. Position Summary: The Senior Manager, Cyber Security Operations is a hands-on leader responsible for building, operating, and continuously improving Ardelyx's security operations capabilities. This role combines technical execution with leadership, requiring a "player-coach" who can both lead the function and actively engage in day-to-day security operations - not a purely strategic role. This is a greenfield opportunity. As Ardelyx transitions from a managed service provider (MSP) model to an internally operated IT and security organization, this individual will help build the security operations function from the ground up. The right candidate thrives in build environments, is energized by consolidating a fragmented security stack onto a modern Microsoft-centric platform, and can operate effectively both as an individual contributor and as a team leader. This role provides operational direction for security operations while ensuring the confidentiality, integrity, and availability of corporate systems, data, and cloud environments. The ideal candidate brings deep technical expertise, operational discipline, and practical leadership, with the ability to communicate effectively with executives, auditors, engineers, and cross-functional teams.

Requirements

• Bachelor’s degree in Information Security, Computer Science, or related field
• 8+ years of progressive cybersecurity experience, with strong focus on security operations and engineering or equivalent experience
• Proven hands-on experience with the Microsoft security stack: Defender for Endpoint, Defender for Identity, Defender for Office 365, and Microsoft Sentinel
• Demonstrated experience with identity and access management: Microsoft Entra ID, MFA, Conditional Access, and Privileged Identity Management (PIM)
• Cloud security experience in Azure (required) and AWS (a plus); ability to monitor and respond to threats across hybrid cloud environments
• Experience leading or building security operations programs including SIEM, vulnerability management, and security automation in an enterprise environment
• Familiarity with compliance frameworks including NIST CSF, ISO 27001, SOC 2, and HIPAA
• Prior experience in a player-coach capacity — comfortable both leading a team and rolling up sleeves on technical execution
• Strong communication skills with the ability to translate technical risk into business impact for executive and non-technical audiences

Nice To Haves

• Relevant certifications preferred (CISSP, CISM, CRISC, CCSP, GCIH, etc.)

Responsibilities

• Lead and actively participate in security incident detection, investigation, and response across endpoint, identity, cloud, and SaaS environments including hands-on alert triage, log analysis, and threat intelligence review
• Lead incident response coordination with Legal, HR, Compliance, and Communications; own post-incident reviews and drive continuous improvement of response processes
• Establish and track key operational metrics (MTTD, MTTR, incident trends) and continuously tune detection rules, playbooks, and SOAR automation to reduce noise and improve signal fidelity
• Own and mature the Microsoft security ecosystem - Defender XDR, Microsoft Sentinel (SIEM/SOAR), and Purview - driving integration, automation, and unified detection and response across the environment
• Design and optimize security controls across endpoint (EDR/XDR), identity (Entra ID, MFA, Conditional Access), Azure, AWS, and SaaS applications; lead vulnerability management operations including scanning, prioritization, and remediation tracking
• Consume and operationalize threat intelligence, integrating indicators into Sentinel detection rules; develop SOAR playbooks via Logic Apps to reduce manual effort and accelerate response
• Initially operate as a hands-on individual contributor while building and mentoring a team of 2 security engineers over the next 3–4 months; provide technical guidance and escalation support on complex issues
• Ensure effective prioritization and coverage across security operations, fostering a culture of operational discipline, continuous learning, and security awareness
• Execute against the cybersecurity roadmap in alignment with business objectives; identify control gaps and implement scalable, practical improvements aligned with the organization's risk tolerance
• Partner with Legal, Compliance, and IT to support audits, risk assessments, and regulatory requirements including NIST CSF 2.0, ISO 27001, SOC 2, and HIPAA; contribute to security policy development and enforcement
• Support third-party risk management, vendor security evaluations, and security platform consolidation efforts to reduce complexity and operational cost

Benefits

• Ardelyx also offers a robust benefits package to employees, including a 401(k) plan with generous employer match, 12 weeks of paid parental leave, up to 12 weeks of living organ and bone marrow leave, equity incentive plans, health plans (medical, prescription drug, dental, and vision), life insurance and disability, flexible time off, annual Winter Holiday shut down, and at least 11 paid holidays.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Number of Employees: 101-250 employees