Senior Engineer II, Applied Technologies

Moderna•Norwood, MA

1d•Onsite

About The Position

Joining Moderna offers the unique opportunity to be part of a pioneering team that's revolutionizing medicine through mRNA technology, with a diverse pipeline of development programs across various diseases. As an employee, you'll be part of a continually growing organization, working alongside exceptional colleagues and strategic partners worldwide, contributing to global health initiatives. Moderna's commitment to advancing the technological frontier of mRNA medicines ensures a challenging and rewarding career experience, with the potential to make a significant impact on patients' lives worldwide. This high-impact individual contributor role will lead the strategy and deployment of Process Analytical Technology (PAT) across Moderna’s mRNA drug substance and drug product platforms. You will architect and implement cutting-edge inline, online, and at-line analytical tools that unlock real-time monitoring and data-driven control from early-stage development through GMP manufacturing. Working across functional boundaries, you will build the digital and analytical backbone of next-generation bioprocessing. This is a unique opportunity to operate at the intersection of automation, advanced analytics, and mRNA science — and to shape how Moderna integrates Generative AI tools and intelligent control systems into its manufacturing future.

Requirements

Ph.D. in Chemical/Biomedical Engineering, Analytical Chemistry, or related discipline with 2+ years, OR M.S. with 8+ years, OR B.S. with 10+ years of relevant industrial experience.
Hands-‑on experience developing and implementing PAT tools in biopharmaceutical or advanced ‑therapy manufacturing environments, including sensor specification, installation, and data ‑modelling, and technology transfer.
Proficient in multivariate data analysis/chemometrics tools (SIMCA, Unscrambler, Python, R) and integration with process automation systems, manufacturing data platforms, and communication protocols (e.g. DeltaV, SynTQ, PI AF, OPC UA).
Strong understanding of Design of Experiment (DoE), cGMP, Quality by Design principles, and process validation fundamentals.
This position is site-based, requiring you to be at Moderna’s site full-time.
This position is not eligible for remote work.

Nice To Haves

Demonstrated authorship of CMC regulatory submissions (IND, IMPD, BLA/MAA) and participation in health authority interactions related to PAT packages, real-time release testing, and continuous manufacturing.
Experience with life cycle management, including GMP compliance and training.
Familiarity with expedited regulatory pathways, EU GMP Annex 1, ATMP/CGT guidances, and relevant ICH (e.g. Q8, Q9, Q10, Q12, Q13).
Expertise with mRNA, lipid nanoparticle formulation, or other nucleic acid-based modalities.
Experience deploying PAT for personalized or small batch therapeutics.
Lean/Six Sigma Green Belt (or higher) and a track record of driving efficiency improvements in GMP settings.
Exceptional communication skills and a collaborative mindset focused on patient impact.
A desire to make an impact as part of a high-growth, transformational company that is Bold, Relentless, Curious, and Collaborative.

Responsibilities

Lead the end-to-end PAT and control strategy, ensuring cross-platform consistency and alignment with Moderna’s digital and automation roadmaps.
Design, deploy, and maintain a diverse suite of spectroscopic, chromatographic, and sensor technologies (e.g., Raman, FTIR, UPLC, rapid sterility, pH/DO micro sensors).
Develop chemometric models and real-time dashboards linking process parameters with critical quality attributes.
Serve as a technical lead on integration of PAT tools into Moderna’s digital ecosystem — including data lakes, electronic batch records (eBR), and advanced process control layers.
Author and lead technology transfer packages to internal GMP sites and external partners, ensuring seamless comparability and calibration approaches.
Collaborate closely with analytical development, MS&T, process automation, digital, engineering, quality, and regulatory teams to ensure PAT solutions are seamlessly manufacturable and inspection-ready.
Drive continuous improvement initiatives that reduce cycle times, enhance right-first-time metrics, and improve overall process robustness.
Mentor staff and champion a scientific culture of curiosity, innovation, and excellence.
Translate complex analytical and regulatory requirements into integrated solutions aligned with Moderna’s next-gen manufacturing platforms.
Travel up to 10%, supporting deployment at domestic and international manufacturing sites.

Benefits

Best-in-class healthcare coverage, plus voluntary benefit programs to support your unique needs
A holistic approach to well-being, with access to fitness, mindfulness, and mental health support
Family planning benefits, including fertility, adoption, and surrogacy support
Generous paid time off, including vacation, volunteer days, sabbatical, global recharge days, and a discretionary year-end shutdown
Savings and investment opportunities to help you plan for the future
Location-specific perks and extras

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