Senior Engineer I

Arcellx•Rockville, MD

2d•$145,000 - $165,000•Onsite

About The Position

We are seeking a Senior Engineer I who is passionate about advancing cell therapy manufacturing. In this role, you will contribute to the development of phase-appropriate manufacturing processes for Arcellx’s cutting-edge cell therapy products. Our mission is to deliver high-quality therapies to clinical patients by leveraging both in-house and external manufacturing capabilities. You will bring expert-level knowledge of CAR-T GMP manufacturing processes and a strong understanding of manufacturing batch records across multiple sites. This role combines technical expertise with hands-on laboratory skills in a Process Development/MSAT environment, driving initiatives in process design, characterization, optimization, and technology transfer to manufacturing sites. This is a high-visibility, impactful position within our Technical Operations organization—ideal for someone who thrives in a collaborative, fast-paced environment and is motivated by making a difference for patients. At Arcellx, we value passion, curiosity, determination, and diversity, and seek individuals who share our mission and values.

Requirements

BS in Chemical, Biological, Biomedical or Biochemical Engineering with 10+ yrs. of relevant experience, MS with 7+ yrs. of relevant experience, or PhD with 3+ years of relevant experience.
Strong engineering, scientific and operational background in implementation of bioprocess unit operations and aseptic cell culture.
Strong understanding of process development, technical transfer, and GMP operations and documentation.

Nice To Haves

Experience with T or B-cell cultures is a plus.
MSAT/Manufacturing experience is a plus.

Responsibilities

Drive Laboratory Studies for Process Development and MSAT/Manufacturing
Plan, organize, and execute lab experiments to support process development and manufacturing activities (e.g., investigations, process improvements, operator training).
Provide technical expertise for T-cell manufacturing process changes, comparability assessments, deviations, investigations, change control, and regulatory submissions.
Maintain accurate documentation, including lab notebooks, SOPs, and technical reports.
Ensure a clean, safe, and compliant laboratory environment; manage equipment and supplies.
Conduct studies on process understanding (e.g., lot-to-lot variability, hold times, software upgrades).
Support technology transfer by testing and validating manufacturing batch records prior to implementation.
Collaborate with internal and external partners (e.g., Analytical Development, Protein Sciences) for testing and related studies.
Meet with MSAT/Manufacturing team regularly to conduct manufacturability assessments of any changes to the manufacturing process
Laboratory Management
Manage purchase orders, vendor relationships, and material ordering for Lab operations
Oversee weekly equipment checks, lab organization, and safety compliance as a Lab Safety Team representative.
Contribute to development plans, process definition, and optimization strategies.
Summarize and present data in team meetings; actively participate in technical discussions.
Troubleshoot and resolve technical challenges independently and collaboratively.
Travel to CA Arcellx Site up to 20% for training in manufacturing support as needed.