Senior Director, Commercial Project Management

Revolution Medicines

9h•Remote

About The Position

Revolution Medicines is a late-stage clinical oncology company dedicated to developing novel targeted therapies for patients with RAS-addicted cancers. The company's R&D pipeline includes several RAS(ON) inhibitors currently in clinical development. This Senior Director, Commercial Project Management role is a highly visible opportunity to establish and scale global commercial project management as a core capability within the newly formed Commercialization Effectiveness & Operations (CE&O) function. The position will be instrumental in translating commercial strategy into disciplined, high-impact execution across a diverse portfolio of global commercial and commercialization initiatives. The successful candidate will partner closely with Global Commercial Leads and cross-functional stakeholders to lead complex, high-impact global Commercial Project Teams, accelerating execution and strengthening operational processes. Operating in a build-while-scaling environment, this leader will help shape how complex, cross-functional work gets done, bringing clarity, structure, and momentum. The role is designed for someone who thrives in ambiguity, is energized by creating fit-for-purpose ways of working, and is motivated by the opportunity to leave a lasting imprint on the organization's operations. As the capability matures, this role is expected to grow into people leadership and broader sub-functional ownership.

Requirements

Bachelor’s degree, with 12+ years of relevant experience in biotech/pharma/healthcare, including significant experience leading complex, cross-functional commercial or commercialization initiatives.
Experience supporting global commercial organizations, including launch readiness, lifecycle management, or major commercialization initiatives.
Experience working across regions and global/local operating models.
Demonstrated Senior Director-level capability: ability to shape scalable practices, lead through influence, and drive change in evolving organizations.
Strong project leadership skills: planning, dependency/risk management, stakeholder leadership, and executive-ready communication.
Proven success partnering with senior commercial leaders and leading execution across functions without direct authority.
Track record of thriving in ambiguous, fast-moving environments with a roll-up-your-sleeves mindset.
Exceptional communication and interpersonal skills, with the ability to translate complexity into clarity for diverse audiences.
Strong judgment, systems thinking, and a solutions-oriented mindset.

Nice To Haves

Advanced degree (MBA/MS/PhD).
Oncology / specialty pharma commercialization experience.
Formal Project Management training or certification (e.g., PMP).
Early people leadership experience or readiness to step into people leadership as the capability scales.

Responsibilities

Lead cross-functional Global Commercial Project Teams in close partnership with Global Commercial Leads, driving clarity, alignment, and progress across priorities and interdependencies.
Own end-to-end project execution for a portfolio of high-priority global commercial and commercialization initiatives (e.g., readiness planning, major commercial initiatives, capability build-outs), ensuring milestones, risks, and dependencies are visible and managed.
Coordinate and integrate inputs across Commercial, Medical, Market Access, Regulatory, Supply/Tech Ops, Legal, Finance, and other partners into cohesive global commercial plans and decision-ready updates.
Proactively identify risks and remove blockers, driving trade-offs and timely decisions through strong stakeholder leadership and executive communication.
Help build and scale global commercial project management capability (tools, templates, dashboards, project rhythms) in partnership with the broader CE&O team — bringing practical structure without over-engineering.
Support governance and ways of working by partnering with CE&O colleagues and functional leaders to strengthen decision-making, accountability, and escalation paths (shared ownership).
Drive continuous improvement and change adoption across projects by capturing learnings, simplifying processes, and strengthening execution discipline.