Senior Director, Cancer Immunology

Revolution Medicines•Redwood City, CA

71d•Hybrid

About The Position

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: This role represents a unique opportunity to serve as a strategic and scientific leader within Cancer Immunology, reporting into the Biology organization. We are seeking a highly motivated, critical thinker with a passion for scientific excellence and innovation, who can drive the discovery and advancement of novel immuno-oncology targets and modalities. The successful candidate will lead a multidisciplinary team, shape the scientific vision for Discovery Cancer Immunology, and provide oversight of scientific integration across both Discovery and Translational Cancer Immunology. As a strategic and scientific leader in Cancer Immunology, you will report into the Vice President and Head of Cancer Immunology. Key aspects of the role include: Discovery Program Leadership & Strategic Oversight: Lead Cancer Immunology discovery programs from project qualification through Development Candidate nomination. Drive the identification and validation of novel immuno-oncology targets, ensuring seamless progression of programs into Translational Cancer Immunology. Platform & Modality Innovation: Oversee the development and optimization of experimental platforms, including in vitro and in vivo models, phenotypic screening, and advanced assay toolkits. Champion the exploration and implementation of new therapeutic modalities, such as TCEs, ADCs, and bispecifics. Scientific Integration & Operational Excellence: Provide strategic oversight of scientific integration across Discovery and Translational Cancer Immunology, ensuring operational rigor, platform support, and alignment of resources. Leverage enabling functions and data-driven insights to enhance experimental design, reproducibility, and program execution. Promote the development and deployment of modern data systems and analytics to advance scientific and operational excellence, enabling the establishment of a digitally empowered Cancer Immunology team within the broader organization. Cross-functional Collaboration: Partner with Research Leadership to support advancement of programs from early discovery into the clinical development portfolio. Foster collaboration across multidisciplinary teams to ensure that discovery efforts, platform capabilities including data platforms, and translational priorities are coordinated and integrated. Team Leadership & Mentorship: Lead, mentor, and inspire a multidisciplinary team of PhD and non-PhD scientists. Cultivate a culture of scientific excellence, innovation, and collaboration. External Engagement: Spearhead collaborations with academic partners and external organizations. Partner with key stakeholders to define publication strategies and support advancement of the company’s scientific reputation in the field.

Requirements

Ph.D. in immunology, cancer biology, or a related discipline, with deep expertise in tumor immunology, immune-evasive oncogenic signaling pathways, and/or immunotherapy.
Demonstrated track record of excellence in research, evidenced by high-impact publications.
Industry Experience: in oncology drug discovery and development, including experience with antibody-directed therapies such as T cell engagers, ADCs, or bispecific antibodies.
Proven ability to lead multidisciplinary teams and cross-functional projects, with excellent people management skills.
Experience in project team leadership and mentoring scientists is strongly preferred.
Strong strategic thinker capable of prioritizing initiatives, anticipating challenges, and executing effectively in a dynamic, high-energy environment.
Rigorous, quantitative, and detail-oriented experimentalist.
Thrives in a collaborative, interdisciplinary team setting.
Excellent written and verbal communication skills, with the ability to influence and align diverse stakeholders.

Nice To Haves

Experience with chemistry-based therapies, including small molecules or ADC payloads.
Familiarity with bioinformatics-driven discovery and integrating computational insights into experimental design.
Demonstrated proficiency with modern data platforms, machine learning approaches, and advanced analytics to support Cancer Immunology research and decision-making.
Prior experience as a Program Team Leader, with a track record of driving cross-functional strategy and execution across discovery and development stages.

Responsibilities

Lead Cancer Immunology discovery programs from project qualification through Development Candidate nomination.
Drive the identification and validation of novel immuno-oncology targets, ensuring seamless progression of programs into Translational Cancer Immunology.
Oversee the development and optimization of experimental platforms, including in vitro and in vivo models, phenotypic screening, and advanced assay toolkits.
Champion the exploration and implementation of new therapeutic modalities, such as TCEs, ADCs, and bispecifics.
Provide strategic oversight of scientific integration across Discovery and Translational Cancer Immunology, ensuring operational rigor, platform support, and alignment of resources.
Leverage enabling functions and data-driven insights to enhance experimental design, reproducibility, and program execution.
Promote the development and deployment of modern data systems and analytics to advance scientific and operational excellence, enabling the establishment of a digitally empowered Cancer Immunology team within the broader organization.
Partner with Research Leadership to support advancement of programs from early discovery into the clinical development portfolio.
Foster collaboration across multidisciplinary teams to ensure that discovery efforts, platform capabilities including data platforms, and translational priorities are coordinated and integrated.
Lead, mentor, and inspire a multidisciplinary team of PhD and non-PhD scientists.
Cultivate a culture of scientific excellence, innovation, and collaboration.
Spearhead collaborations with academic partners and external organizations.
Partner with key stakeholders to define publication strategies and support advancement of the company’s scientific reputation in the field.