Senior Director, Business Applications

Olema Oncology•Boston, MA

6h•$270,000 - $290,000•Hybrid

About The Position

As the Senior Director, Business Applications reporting to the Vice President, Information Technology, you are a seasoned and visionary Senior Director who will oversee and optimize all General & Administrative (G&A) business systems. You will lead a high-impact team in enhancing, hardening, and scaling enterprise systems to support Olema’s transition toward commercialization and sustained growth. This is a unique opportunity to make a meaningful impact at a dynamic biotech company during a pivotal phase in its development. This role is based in either our San Francisco or Boston office and will require 10% travel.

Requirements

Bachelor's degree in information systems, computer science, or related discipline; advanced degree preferred
Strong knowledge of AI technologies, data management, and automation tools to drive digital transformation
Demonstrated leadership in managing cross-functional teams and complex system implementations
Proven success scaling and hardening systems in preparation for commercialization
Demonstrated ability to translate business requirements into technical solutions and architect scalable, future-ready systems
A minimum of 10+ years of experience managing enterprise applications, with a strong background in G&A systems within the biotech or pharmaceutical industry
A minimum of 5+ years of experience building, leading, managing, developing and mentoring direct reports
Hands-on experience with NetSuite is a must. Prendio, Agiloft, BambooHR, Greenhouse, and Culture Amp, Workato or similar tools highly preferred
Track record of process optimization, workflow automation, and driving operational efficiency
Experience working within or preparing organizations for SOX compliance, including system controls, audit requirements, and governance
Proven success in system and vendor selection, including leading evaluations, RFPs, and contract negotiations
Exceptional communication skills and the ability to influence stakeholders at all levels of the organization
Strong commitment to excellence and delivering outstanding user experiences
Highly analytical and data-driven decision-maker
Proactive, self-motivated, and results-oriented with a "bias for action"
Collaborative team player who thrives in a cross-functional environment
Flexible and adaptable to evolving business needs and technology trends

Responsibilities

Own the strategic roadmap, budget and day-to-day management of G&A business systems including NetSuite, Prendio, Agiloft, BambooHR, Greenhouse, and Culture Amp
Hardening existing systems to prepare for commercialization and ensure enterprise scalability, audit readiness, and compliance with SOX (404A & B) requirements
Partner with Finance, HR, Legal, Procurement, Talent, Facilities and IT teams to understand evolving business requirements and deliver efficient, scalable solutions
Ensure successful adoption of new technologies and enhancements through structured change management practices, including communication, training, and stakeholder alignment
Evaluate and implement AI-driven tools and automation platforms, and workflow optimization solutions – such as Workato or similar iPaas technologies - to improve business performance and operational efficiency
Drive continuous improvement and digital transformation efforts by identifying opportunities for process redesign, automation and integration across systems
Ensure application governance, data integrity, system security, and adherence to internal controls and SOX processes
Lead system and vendor evaluations, platform assessments, and RFP processes to achieve the optimal technical fit and value for the organization
Manage vendor relationships and contract negotiations for SaaS platforms and service providers
Provide oversight and partnership with R&D teams (~10–15% of your time) to support scientific applications, data workflows, and system integrations that enable research innovation
Mentor and grow a high-performing Business Applications team aligned with Olema’s culture and mission