The Senior Bioinformatics Analyst is responsible for designing, developing, and operating structured databases and analysis pipelines to optimize usage and accessibility. Manages data integration and coordinates other efforts related to infrastructure with minimal supervision. The Northcott Lab within the Center of Excellence in Neuro-Oncology Sciences (CENOS) is seeking a highly motivated Senior Bioinformatics Analyst. The CENOS is a collaborative translational research program with a mission to improve survival and morbidity for children with brain tumors. Through application of cutting-edge molecular approaches to unique and data-rich cohorts, members of this program are efficiently translating laboratory findings into clinical practice and treatment innovations. The successful candidate will contribute to the management, usage, and accessibility of unprecedented multi-‘omics datasets obtained from children with malignant brain cancer. Through application of structured/unstructured databases, storage and integration of large multi-modal datasets, including bulk, single-cell, and spatial profiles, we aim to make novel insights with real-world clinical implications. The candidate will work closely with bioinformatics personnel within the CENOS to play a role in exciting collaborations, both within St. Jude and with prominent external collaborators. A deep understanding of database development, maintenance, and optimization are essential for this position. The successful recruit must have the capacity to execute proficient data storage, management, and integration strategies and troubleshoot independently, communicate effectively with the PI and collaborators across diverse disciplines, and thrive in a highly collaborative team environment.