Senior Associate Scientist

GSKUpper Providence Township, PA
22dOnsite

About The Position

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success. GSK has kicked off 2025 with impressive growth in sales, profits, and earnings. We anticipate five major new FDA product approvals and 15 phase III/pivotal study readouts over the next two years. So far, we have secured two FDA approvals, with three more expected later this year. By uniting science, technology, and talent, we are committed to getting ahead of disease together. We are seeking a highly motivated and experienced Scientist to join our iPSC Systems team within the Human Biology - Target Discovery department at GSK's Upper Providence research facility in the United States. This full-time, on-site lab-based role is dedicated to advancing iPSC-derived translational models’ development, with a focus on neurodegenerative diseases such as Alzheimer's Disease. The ideal candidate will have in-depth expertise in iPSC culture and differentiation, complemented by a solid foundation in molecular biology and data analysis techniques. Automated liquid handling and data analysis experience required. This position requires proficiency in developing, troubleshooting, and refining conditions to develop disease-relevant models critical for target identification and target validation at scale. Our team thrives through collaboration with diverse research units and platform groups, fostering a vibrant environment that encourages cross-disciplinary projects, scientific excellence, and problem-solving. This is a lab-based position with mandatory on-site presence at our Upper Providence location.

Requirements

  • Bachelor's or master’s degree in Biochemistry, Molecular and Cellular Biology, Neuroscience, or related field, with 5+ or 3+ years of experience in iPSC-model development.
  • Experience in iPSC culture and differentiation.
  • Experience in genetic, proteomic, imaging, and other 'omics technologies analytical pipelines.
  • Experience in neurodegenerative diseases.

Nice To Haves

  • Experience in programming and operating automated liquid handling systems.
  • Strong skills in relationship building, adaptable thinking, and troubleshooting.
  • Experience conducting perturbation studies using tool compounds and gene editing techniques, preferably CRISPRn/i/a.

Responsibilities

  • Develop physiological and disease-relevant cellular models and refine assays to achieve research objectives.
  • Communicate experimental findings effectively, both in writing and verbally, to stakeholders.
  • Ensure compliance with all GSK R&D integrity practices, ethical codes, standards, and safety protocols.
  • Collaborate in a matrix team environment, contributing to achieve high scientific standards and project success.
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