Senior Associate Scientist, Process Sciences

Alnylam Pharmaceuticals

9d•Onsite

About The Position

Overview: The successful candidate will be a part of the Process Chemistry group, responsible for the process development and in-house non-GMP manufacture of modified oligonucleotides and siRNAs. The successful candidate must have a strong commitment to preserving a high laboratory and scientific standard, and maintaining a safe, clean, and orderly laboratory work environment. The incumbent will assist in routine lab and equipment maintenance and well as assist with vendor contract and requisitions as needed. This position is onsite and will be primarily located in Cambridge, MA. Responsibilities: Participate in oligonucleotide purification activities such as method development, optimization, and scale-up chromatography activities Assistance of downstream production activities, as well as method development and optimization Execution of various in-process analytical tests The creation, review, and usage of SOPs and batch records employed for the in-house non-GMP oligonucleotide Execution of oligonucleotide downstream processes to provide the research and in-house non-GMP material in a tight timeline. Qualifications: BS in chemistry, chemical engineering, biochemical engineering, or related field with minimum 1 year lab experience, preferably in an industrial setting. Experience with oligonucleotides, including knowledge of phosphoramidite chemistry, chromatography, ultrafiltration etc. Experience in analytical techniques (pH, osmolality, conductivity measurement, HPLC, LC-MS etc.), or related hands-on experience is preferred. Good understanding of analytical techniques (pH, osmolality, conductivity measurement, HPLC, LC-MS etc.). Related hands-on experience is preferred. Experience in record-keeping and excellent laboratory documentation practices, are required Excellent written and oral communication skills, good organization skills, and multi-tasking abilities. U.S. Pay Range $82,700.00 - $111,900.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

Requirements

BS in chemistry, chemical engineering, biochemical engineering, or related field with minimum 1 year lab experience, preferably in an industrial setting.
Experience with oligonucleotides, including knowledge of phosphoramidite chemistry, chromatography, ultrafiltration etc.
Experience in record-keeping and excellent laboratory documentation practices, are required
Excellent written and oral communication skills, good organization skills, and multi-tasking abilities.

Nice To Haves

Experience in analytical techniques (pH, osmolality, conductivity measurement, HPLC, LC-MS etc.), or related hands-on experience is preferred.
Good understanding of analytical techniques (pH, osmolality, conductivity measurement, HPLC, LC-MS etc.). Related hands-on experience is preferred.

Responsibilities

Participate in oligonucleotide purification activities such as method development, optimization, and scale-up chromatography activities
Assistance of downstream production activities, as well as method development and optimization
Execution of various in-process analytical tests
The creation, review, and usage of SOPs and batch records employed for the in-house non-GMP oligonucleotide
Execution of oligonucleotide downstream processes to provide the research and in-house non-GMP material in a tight timeline.