Senior Associate Scientist, Process Sciences

Alnylam Pharmaceuticals

2d • Onsite

About The Position

The successful candidate will be a part of the Process Science group, responsible for process development, in-house non-GMP manufacturing, report and protocol authoring and reviewing, process transfer to CMOs, and stage 1 manufacturing process validation for siRNA oligonucleotides. This role is fully onsite and lab-based, with the primary location in Cambridge, MA.

Requirements

• BS in Chemical Engineering or Chemistry with a minimum of 2 years lab experience, preferably in an industrial setting.
• Basic understanding of analytical techniques (pH, osmolality, conductivity measurement, HPLC, LC-MS etc.). Related hands-on experience is preferred.
• Experience in record-keeping and excellent laboratory documentation practice, are required. Strong commitment to high laboratory and scientific standard.

Nice To Haves

• Knowledge of oligonucleotide manufacture process including phosphoramidite chemistry, chromatography, ultrafiltration etc. is a plus.

Responsibilities

• Design and conduct laboratory experiments, analyze results, and draw meaningful conclusions.
• Support downstream processing method optimization.
• Execution of oligonucleotide downstream processes to provide the research and in-house non-GMP material in a tight timeline.
• Execution of in-process analytical tests.
• Participate in creating and reviewing SOPs and batch records in support of the in-house non-GMP manufacture.
• Oligonucleotide manufacturing, process development, optimization and scale up.
• Operation and optimization of downstream processing.
• Manufacturing of oligonucleotide APIs in a cGLP environment.
• Operation of analytical instruments and application of analytical techniques.

Benefits

• We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match.
• Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks.
• We also offer generous family resources and leave.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Number of Employees: 1,001-5,000 employees