Senior Associate Scientist, Analytical Development for Characterization

Vaxcyte•San Carlos, CA

6d•$118,000 - $138,000•Onsite

About The Position

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance. WHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values: RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. MODEL EXCELLENCE: The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making. Summary: We are seeking a highly skilled and motivated Senior Associate Scientist to join our Analytical Development team at Vaxcyte. The primary responsibility will be to support characterization of drug substances, intermediates and drug products by LCMS or other appropriate analytical methods. The ideal candidate will embody and uphold our core values of rethinking convention, aiming high, leading with heart, and modeling excellence in all aspects of their work.

Requirements

BS in Chemistry, Analytical Chemistry preferred, Biochemistry/Molecular Biology considered, with 5+ years of relevant industry experience, or MS with 3+ years of experience. Other combinations of education and/or experience may be considered.
Strong knowledge on mass spectrometry technologies, including Orbitrap, QTOF and triple quadrupole.
Hands-on experience with peptide mapping and intact analysis by LCMS.
Highly organized, strong attention to details and excellent record keeping/documentation abilities.
Demonstrate critical thinking and scientific curiosity while approaching complex problems.
Eager and able to learn and understand new concepts with ease.
Strong people skills and ability to communicate effectively with other team members.
Ability to work under supervision and collaborate effectively with other team members in a demanding environment.

Nice To Haves

Knowledge of NMR is a plus.
Experience with peptide quantitation is preferred.

Responsibilities

Independently perform and complete laboratory assignments with high quality and in a timely manner.
Prepare samples and execute analytical procedures according to the SOP.
Perform critical data analysis.
Assist in design, developing and implementing mass spectrometry-based workflows for characterization of proteins, conjugates, and other in-process molecules.
Operate, maintain, and troubleshoot mass spectrometry instruments.
Document results of analyses and experiments with an electronic notebook system.
Support cross-functional teams with their analytic needs based on mass spectrometry.
Interpret, communicate, and present findings and results regularly at group meetings.