Senior Scientist I, Analytical Development

LGC Group•Petaluma, CA

18h

About The Position

The Senior Scientist I, Analytical Development at LGC AxoLabs will serve as a subject matter expert (SME) in analytical method development and validation for oligonucleotide drug substances within a Contract Manufacturing Organization (CMO) environment. This role involves leading analytical initiatives, providing technical guidance to cross-functional teams, and engaging with clients to ensure the accurate characterization and in-process testing of oligonucleotide API and raw materials in compliance with regulatory standards. LGC AxoLabs has an extensive, ever-evolving global client base and impressive technical capabilities within a state-of-the-art GMP facility. As the organization continues to grow, we seek technically adept and highly motivated candidates who can contribute to innovative solutions in oligonucleotide analytical development. The successful candidate will be detail-oriented, proficient in advanced analytical chemistry techniques, and experienced in oligonucleotide analysis. This role requires strong problem-solving skills, technical leadership, and direct interaction with clients to support their project needs.

Requirements

Bachelor’s degree in Chemistry, Biology, Biochemistry, or related discipline with 7+ years of applicable experience, or Master’s degree with 5+ years, or Ph.D. with 0–3 years of experience in a related field.
Advanced technical understanding of oligonucleotide manufacturing processes and hands-on experience with relevant analytical techniques (i.e. HPLC-MS, GC-FID, etc) and equipment.
Working knowledge of chromatography and/or other software including ChemDraw, JMP, Empower, MassLynx, Chromeleon, and/or Waters Connect.
Self-starter with strong problem-solving skills and the ability to work independently and collaboratively within cross-functional teams.
Strong communication skills, both written and verbal, to effectively present data and collaborate with internal teams and external partners.
Ability to manage multiple analytical projects simultaneously while maintaining attention to detail and deliverable timelines.
Demonstrated commitment to scientific excellence and alignment with LGC’s core values and quality standards.

Nice To Haves

Prior experience in a GMP-regulated environment within a CMO/CDMO or pharmaceutical manufacturing setting is strongly preferred.

Responsibilities

Serve as a subject matter expert (SME) in analytical HPLC method development and validation for oligonucleotide APIs and raw materials.
Independently design, execute, and interpret complex analytical studies, including forced degradation, MS/MS sequencing, and stability studies.
Lead technical discussions with internal teams and clients to define analytical strategies, troubleshoot challenges, and drive project deliverables.
Author and review technical documentation, including method development reports, validation protocols, Standard Operating Procedures (SOPs), and regulatory submission materials.
Collaborate with cross-functional teams (e.g., Process Development, Quality Control, and Manufacturing) to integrate analytical solutions into oligonucleotide production workflows.
Maintain working knowledge of relevant regulatory and pharmacopeia guidelines (FDA/ICH/USP) to ensure compliance across analytical activities.
Provide mentorship and technical guidance to junior scientists, supporting skill development and scientific excellence within the team.

Benefits

Competitive compensation with strong bonus program
Comprehensive medical, dental, and vision benefits for employees and dependents
FSA/HSA
Pre-tax savings plans for health care, childcare, and elder care
Deductible Buffer Insurance and Critical Illness Insurance
401(k) retirement plan with matching employer contribution
Company-paid short- and long- term disability, life insurance, and employee assistance program
Flexible work options
Pet Insurance for our furry friends
Enhanced Parental leave of 8 additional weeks
PTO that begins immediately
Town Hall monthly meeting onsite/virtual, Cheer program where employees are recognized for outstanding work, Company wide social events, frequent catered lunches and much more!