Scientist

Legend Biotech Corp•Philadelphia, PA

71d•Hybrid

About The Position

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide. Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma. Legend Biotech is seeking Scientist as part of the Exploratory Technology team based in Philadelphia, PA. Role Overview We are seeking a R&D scientist (Pipeline support) who possesses extensive knowledge and research experience in lentivirus production and cell immunotherapy to support our in vivo CAR T cell therapy program. The candidate is responsible for contributing to in vivo CAR delivery platform optimization and pipeline development.

Requirements

PhD in biological sciences such as Immunology, Cell biology and Biochemistry.
2 - 3 years postdoc experience. Experience in biotech companies is a plus.
IT Skills: Microsoft office, Flowjo, GraphPad Prism.

Responsibilities

Produce research grade lentivirus to support in vitro studies performed in the R&D team
Perform lentivirus titering such as p24 ELISA and qPCR
Setup in vitro CAR T cell culture, characterization and functional assays including PBMC culture, T cell isolation and expansion, multi-color flow cytometry, cytotoxic assays (e.g. IncuCyte), cytokine detection (e.g. MSD) and VCN analysis.
Independently design and execute experiments and at the same time, work closely with the team and cross-functional teams in a highly collaborative environment
Deliver reliable and consistent data and be able to interpret scientific results and present the data within research team and cross-functional teams
Complete ELN in a timely manner with good documentation skills.
Support laboratory chores as a good team player
Experience to support project from early research to clinical stage is a plus
Stay alert to industry development, keep learning and be comfortable in a fast-paced team
Has the authority to make decisions related to technical direction, methodologies, approaches for experiment setup.

Benefits

We are committed to creating a workplace where employees can thrive - both professionally and personally. To attract and retain top talent in a highly competitive industry, we offer a best-in-class benefits package that supports well-being, financial stability, and long-term career growth.
Our offerings are designed to meet the diverse needs of our team members and their families, ensuring they feel valued and supported every step of the way.
Highlights include medical, dental, and vision insurance as well as a 401(k)-retirement plan with company match that vest fully on day one.
Equity and stock options are available to employees in eligible roles, we offer eight weeks of paid parental leave after just three months of employment, and a paid time off policy that includes 15 vacation days, 5 personal days, 5 sick days, 11 U.S. national holidays, and 3 floating holidays.
Additional benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance.
We also provide commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs - demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work.

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