CAMBRIDGE BASED)

Ring Therapeutics•Cambridge, MA

About The Position

Ring Therapeutics Inc. is a privately held, early-stage biotechnology company pioneering a completely novel form of self-assembly nanostructures by exploiting a family of naturally occurring commensal viruses to create the first re-doseable and targetable medicines utilizing a variety of payloads, such as oligos, small molecules, and DNA. This approach enables a powerful new class of tropic, persistent, non-integrating vectors that overcome the immunogenicity, and limited tropism of existing gene therapy vectors. Ring Therapeutics is leveraging this versatile technology to develop a broad pipeline of novel, targeted medicines for disease with high unmet medical need. Ring Therapeutics was founded by Flagship Pioneering, focused on launching breakthrough companies based on internally conceived innovations and insights. Flagship Pioneering has created over 40 groundbreaking companies over the past fifteen years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Seres Therapeutics (NASDAQ:MCRB), , , and Indigo Agriculture. Position Summary We are seeking a Scientist or Senior Scientist to join our Targeting team to support a development of the antibody-based targeting platform for delivering therapeutic modalities. This role is centered on the development of targeted delivery approaches together with designing and developing in vitro assays to evaluate targeting strategies. The ideal candidate brings deep expertise in cell-based and biochemical assay development, and can generate high-quality, decision-driving data across binding, internalization, and functional activity. Experience with or exposure to bioconjugation approaches is desirable to support assay inputs and interpretation. This is a highly collaborative hands-on role requiring scientific independence and a strong focus on building predictive assays directly inform targeted design and delivery candidate selection.

Requirements

Ph.D. in Biology, Biochemistry, Bioengineering, or related field (0–2 years industry experience), or M.S. with 3–5 years relevant experience
Strong, hands-on experience in in vitro assay development, with emphasis on cell-based assays
Experience with flow cytometry–based assays, internalization assays, or similar cellular readouts
Experience with binding and interaction assays (e.g., BLI, ELISA)
Experience with primary cells and other mammalian cell culture systems
Familiarity with or exposure to bioconjugation techniques (e.g., protein labeling or conjugation)
Strong data analysis, interpretation, and troubleshooting skills
Demonstrated ability to lead projects and drive scientific strategy
Proven track record of independent assay development and execution leading to robust, scalable, and decision-enabling assay systems
Experience mentoring junior scientists and contributing to scientific direction
Strong experimental design and troubleshooting skills
Experience in in vitro and biochemical assay development and optimization
Ability to generate quantitative, decision-driving data
Clear scientific communication and data presentation
Collaborative, execution-focused mindset with high attention to detail

Nice To Haves

Industry experience in ADC, bioconjugates or biologics discovery
Experience with targeted delivery systems or nanoparticles
Experience supporting screening and ranking of conjugated molecules or biologics
Familiarity with ligand-receptor biology
Experience with data analysis tools (e.g., Prism, FlowJo)
Experience working in cross-functional drug discovery teams

Responsibilities

Design and optimization of in vitro assays (cell-based and biochemical) to evaluate targeting approaches and function
Establish and maintain relevant cell-based models
Support development of quantitative and reproducible assay workflows to assess binding (e.g. BLI, ELISA), internalization, receptor engagement, and cytotoxicity
Apply bioconjugation methods (e.g., protein labeling and conjugation) as needed to enable assay development and screening
Generate high-quality datasets to drive targeted delivery candidate selection and structure-activity relationship
Collaborate cross-functionally with payload, protein engineering, analytical, and translational teams to ensure assay outputs align with program needs
Present data clearly and provide actionable recommendations to project teams
Maintain rigorous experimental documentation and reproducibility standards

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