GPCR Focused)

Deep Apple Therapeutics•South San Francisco, CA

About The Position

Deep Apple Therapeutics is a Bay Area biotechnology company with a focus on combining capabilities in molecular docking and structural biology to create a nucleus for accelerated drug discovery through advanced computer aided drug design technologies. Deep Apple Therapeutics is applying a state-of-the-art technology research platform based on advanced computational modeling and large-scale compound docking (LSD), cryo-EM based structural biology, and deep learning to drug discovery. We are seeking a highly motivated and Scientist/Senior Scientist, experienced in Biochemistry/Structural Biology specializing in Cryo-Electron Microscopy (Cryo-EM) of G protein-coupled receptors (GPCRs) or other membrane proteins to join a dynamic and well-funded research organization. Deep Apple Therapeutics offers a highly competitive compensation, equity, and benefits package. The successful candidate will assist structural biology efforts to elucidate high-resolution structures of GPCR complexes, contributing to the discovery and development of novel therapeutics. This role requires deep expertise in protein biochemistry, structural biology, and Cryo-EM.

Requirements

Ph.D. in Biochemistry, Structural Biology, Biophysics, or a related field.
Preferred post-doctoral or industry experience in structural biology with a focus on membrane proteins and Cryo-EM.
Proven track record of high-resolution structure determination using Cryo-EM.
Expertise in protein expression, purification, and biochemical characterization.
Proficiency with Cryo-EM software pipelines (e.g., CryoSPARC, Relion & Coot).
Strong publication record demonstrating expertise in Cryo-EM and structural biology.
Excellent problem-solving skills and ability to manage multiple projects simultaneously.
Strong leadership, communication, and team collaboration skills.

Nice To Haves

Experience with membrane proteins or multi-protein complexes especially GPCRs.
Familiarity with integrative structural biology and biophysics approaches.
Experience in the pharmaceutical or biotech industry.
Understanding of drug discovery and development processes.

Responsibilities

Design and execute Cryo-EM experiments for structure determination of challenging biomolecular complexes.
Oversee sample preparation, data collection, image processing, and model building.
Develop and implement strategies to improve Cryo-EM workflows and structural outputs.
Lead efforts in protein engineering, purification, and characterization to ensure high-quality samples for structural studies.
Optimize protein stability and homogeneity for Cryo-EM applications.
Work closely with computational chemists, medicinal chemists, and biologists to integrate structural data into drug design.
Analyze Cryo-EM and structural data to derive meaningful insights.
Present findings to internal stakeholders and external collaborators.
Author high-impact publications and contribute to intellectual property filings.