Scientist/Senior Scientist, Antibody Engineering

Arrowhead Pharmaceuticals, Inc.•San Diego, CA

54d

About The Position

We are seeking a highly motivated and skilled Molecular Biologist to join our dynamic research team in Discovery Chemistry,. The successful candidate will play a key role in antibody engineering to support platform development and drug delivery initiatives. This position requires extensive hands-on experience in phage display, antibody engineering, and antibody characterization, supported by a strong foundation in molecular biology.

Requirements

Ph.D. in Biology, Biochemistry, Molecular Biology, or a related field.
Hands-on experience with phage display technology for antibody engineering.
Proficiency in molecular cloning, PCR, and mutagenesis.
Experience with antibody expression and purification using E. coli, HEK293, and CHO systems.
Strong analytical and problem-solving skills, with the ability to troubleshoot experiments independently.
Excellent record-keeping, communication, and collaboration skills.
Proven ability to adapt to fast pace and evolving research priorities
Track record of scientific productivity, including peer-reviewed publications, conference presentations, or patents
Additional experience in molecular biology and/or antibody discovery is highly desirable

Nice To Haves

Industry or postdoc experience

Responsibilities

Design and construct mutant phage libraries for antibody affinity maturation or humanization.
Perform molecular cloning, mutagenesis, antibody gene assembly, and expression vector design.
Express and purify recombinant antibodies using bacterial and mammalian expression systems.
Perform binding, specific and in vitro functional assays.
Collaborate with cross-functional project teams to advance lead antibodies through drug development stages.
Maintain accurate documentation and present findings at internal meetings.

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