(Senior) Scientist, ML/AI Antibody Design
About The Position
FL108 Inc., is a privately held, early-stage biotechnology company focused on developing novel protein-based delivery modalities. FL108 is backed by Flagship Pioneering, bringing the vision and resources to guide FL108 from platform validation to real-world solutions that meaningfully improve patient care. We are seeking a passionate, creative, and self-driven (senior) scientist with expertise in computational protein design and state of the art AI/ML tooling for antibody and protein design to join our team. This candidate will pioneer the design of novel protein-based delivery modalities and collaborate with the experimental teams to test and iterate on computational designs. S/he will thrive in an entrepreneurial, fast-paced, and highly collaborative start-up environment, with the opportunity to work closely with Flagship Pioneering founders and become a leader in advancing FL108’s scientific platform and patient-focused mission.
Requirements
- Ph.D. (with 2+ yrs of industry research experience ) in computational protein design, protein biochemistry, computational biophysics, computational biology, physics, or related field
- Expertise in computational protein modeling and design, structural biology, and biophysics is required
- Deep expertise with ML tools for computational protein design such as AlphaFold, RosettaFold, ESMFold, ProteinMPNN, RFDiffusion, Chroma, IgFold, DeepAb, Parapredis is required
- Strategic thinker, able to shift seamlessly between rigorous scientific details and high-level context and implications
- Instinctive team player with excellent communication skills and great attention to detail
Nice To Haves
- Experience with antibody and/or nanobody modeling and design is strongly preferred.
- Knowledge of critical wet-lab techniques used in protein engineering such as phage display, SPR, ITC, CD-spectroscopy is preferred
Responsibilities
- Drive the AI/ML computational protein design
- Engage with Pioneering Intelligence at Flagship to explore and implement novel ML models that benefit FL108 design principles
- Advance both antibody engineering and de novo antibody design pipelines
- Collaborate closely with the Fl108 experimental scientists to test and iterate on constructs
- Engineer novel functionalities into protein scaffolds, leveraging structural modeling, rational design, and/or directed evolution
- Be abreast of the computational protein design field to advise design and strategic directions for protein engineering, implementing the latest technologies where necessary
- Contribute to strategic direction of the computational team at FL108, helping shape our design platform at the forefront of scientific innovation
- Identify and lead external research relationships with academic and commercial partners
- Report results to scientific team and Flagship Pioneering management
Benefits
- FL108 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
Number of Employees
251-500 employees
